DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mitf and Tfe3

DIOPT Version :9

Sequence 1:	NP_001245436.1	Gene:	Mitf / 3885647	FlyBaseID:	FBgn0263112	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_766060.2	Gene:	Tfe3 / 209446	MGIID:	98511	Length:	572	Species:	Mus musculus

Alignment Length:	733	Identity:	198/733 - (27%)
Similarity:	281/733 - (38%)	Gaps:	251/733 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LCMTNIRVSVGIDKDLEMILEMDP-SIVDLGD----------ISIDET-AEPRIVGLPPLSGGP- 169
            |.:.::....||..|:|:...:|| |..:|..          ||:..| ..|..:.....:||.
Mouse    38 LSLNSLLPESGIVADIELENILDPDSFYELKSQPLSLRSSLPISLQATPTTPATLSASSSAGGSR 102

  Fly   170 TFKTATPTSRTQLKLQLQREQQQQMMIQQQTLDTAMDPKMHLLFGSGQGLMESEFIDSGSTSACG 234
            |...::.:||..|:.||.|.|.|:...:::....|..|            ..|....|.:.|..|
Mouse   103 TPAMSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAP------------FPSPAPASPAISVIG 155

  Fly   235 SGSSSLEQMSQLVQMDNLIDSSSGAKLKVPLQSIGVDVPPQVLQVSTVLENPTRYHVIQKQKNQV 299
            .                   |:.|..|..|..:   .||.:||:|.|.||||||||:.|.::.||
Mouse   156 V-------------------SAGGHTLSRPPPA---QVPREVLKVQTHLENPTRYHLQQARRQQV 198

  Fly   300 RQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPS 364
            :||||.:..|          |||:.:
Mouse   199 KQYLSTTLGP----------KLASQA--------------------------------------- 214

  Fly   365 DDAMPISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSL-------SST 422
                 ::|            |..|:..:|    ...||.||.|...| |..||.:       ||.
Mouse   215 -----LTP------------PPGPSSAQP----LPAPETAHATGPTG-SAPNSPMALLTIGSSSE 257

  Fly   423 RSSSGIVNSIRISSTSS----------------SLQSTSAPISPSVSSVATS--VSEPDDIFDDI 469
            :....:::.| ||..||                .|.|| .|:|.::..|.:|  |:.|
Mouse   258 KEIDDVIDEI-ISLESSYNDEMLSYLPGGTAGLQLPST-LPVSGNLLDVYSSQGVATP------- 313

  Fly   470 LQNDSFNFDKNFNSEL-SIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTL 533
                :.....:..:|| :||:|   :::.|..||.|:||||||||:|||||||||||||||||||
Mouse   314 ----AITVSNSCPAELPNIKRE---ISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTL 371

  Fly   534 LPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELE 598
            :||.:|.      ::|.|||||||:|||||:.|:.|..|.:..|.|||.:|..||.|..||:|||
Mouse   372 IPKSNDP------EMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELE 430

  Fly   599 MQAKSHGILLSENHLTSLSAPTQPYLKSFSLSPTASRSRRSLFDQPVEKKIQVIDGADGNMGMNQ 663
            :||:.||          |..|..|.|    ||.|.|....||  :|.:..|:
Mouse   431 LQAQIHG----------LPVPPNPGL----LSLTTSSVSDSL--KPEQLDIE------------- 466

  Fly   664 VDEFMEDCKYAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSFEPKNFSEADESLFRGKSSLASDD 728
             :|......:.|.||.   :.::..|..|..||...|:
Mouse   467 -EEGRPSTTFHVSGGP---AQNAPPQQPPAPPSDALLD--------------------------- 500

  Fly   729 CCGINCSTSCYIQHQLTSREGHPNHSHHTGIREI----HSLSDSAQNSEFSRLEHCDDPLLS--- 786
                        .|..:...|......|.|:.:|    ..:.........|.|....|||||
Mouse   501 ------------LHFPSDHLGDLGDPFHLGLEDILMEEEGMVGGLSGGALSPLRAASDPLLSSVS 553

  Fly   787 ------SSHRSLGTVDED 798
                  ||.||..:::|:
Mouse   554 PAVSKASSRRSSFSMEEE 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	22/38 (58%)
Mitf	NP_001245436.1	HLH	505..570	CDD:238036	44/64 (69%)
Tfe3	NP_766060.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..152		16/76 (21%)
		MITF_TFEB_C_3_N	112..264	CDD:318217	57/256 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..248		15/98 (15%)
		Strong transcription activation domain. /evidence=ECO:0000255	259..270		2/11 (18%)
		HLH	343..403	CDD:238036	45/65 (69%)
		Leucine-zipper	408..429		10/20 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..495		17/78 (22%)
		DUF3371	<518..570	CDD:314681	13/51 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..572		12/42 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847998
Domainoid	1	1.000	85	1.000	Domainoid score	I8160
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4416
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1211990at2759
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		otm43034
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45776
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	1	1.000	-	-		X566
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.890