Protein Alignment Mitf and Srebf2

DIOPT Version :9

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_150087.1
• Gene: Srebf2 / 20788
• MGIID: 107585
• Length: 1130
• Species: Mus musculus
• Alignment Length: 527
• Identity: 101/527 - (19%)
• Similarity: 188/527 - (35%)
• Gaps: 172/527 - (32%)

  Fly   222 SEFIDSGSTSACGSGSS-----------SLEQMSQLVQMDNLIDSSSGAKLKVPLQSIGVD---- 271
            |.|...||....|:.||           ::::....|.:...  |.|.|..:.|...:.|.
Mouse    52 SSFPGGGSNGGSGNNSSGRGNNGGATDPAVQRSFSQVPLSTF--SPSAASPQAPALQVKVSPTPP 114

  Fly   272 --------------VPPQVLQVSTVLENPT-----RYHVIQKQKNQVRQYLSESF---KPSMWGS 314
                          .||..||..||:..||     :..:||:.  .:.|..:.||   :|.:...
Mouse   115 RATPVLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQP--LIYQNAATSFQVLQPQVQSL 177

  Fly   315 HTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIM---PSDDAMPISPFGGS 376
            .||.           .:|..::|:.:             ..|.|:|::   .:.....::|....
Mouse   178 VTSP-----------QVQPVTIQQQV-------------QTVQAQRVLTQTANGTLQTLAPATVQ 218

  Fly   377 FVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSSSGIVNSIRISSTSSSL 441
            .|....:..: |.:::|.                 :.|.:|.:.:|..:.|  :.:..:..:.:|
Mouse   219 TVAAPQVQQV-PVLVQPQ-----------------IIKTDSLVLTTLKTDG--SPVMAAVQNPAL 263

  Fly   442 QSTSAPISPSVSSVATSVSEPDDIFD--DILQNDSFNFDKNFNSELSIKQEPQNLTDAEMNALAK 504
            .:.:|||..:...|.|.|.....|..  .::..         ..::.|||.|..:...:.   .|
Mouse   264 TALTAPIQTAALQVPTLVGSNGTILTTMPVMMG---------QEKVPIKQVPGGVKQLDP---PK 316

  Fly   505 DRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHE 569
            :.:::..||:||:|.|.:|||:|.||..|: .|:||        :.:|..:|:.::||||.|:..
Mouse   317 EGERRTTHNIIEKRYRSSINDKIIELKDLV-MGTDA--------KMHKSGVLRKAIDYIKYLQQV 372

  Fly   570 VTRLRQNELRQRQVELQNRK-----------LMSRIKELEMQAKSHGILLSENHLTSLSAPTQPY 623
            ..:|||..:   .::|.|:|           |:....:|::...:..:||
Mouse   373 NHKLRQENM---VLKLANQKNKLLKGIDLGSLVDSDVDLKIDDFNQNVLL--------------- 419

  Fly   624 LKSFSLSPTASRSRRSLFDQPVEKKIQVIDGADGNMGMNQVDEFMEDCKYAVQGGDPMLSSHSHM 688
                 :||.||.|                 |:........:|.         :.|.|:|.. :.:
Mouse   420 -----MSPPASDS-----------------GSQAGFSPYSIDS---------EPGSPLLDD-AKV 452

  Fly   689 QSAPQSP 695
            :..|.||
Mouse   453 KDEPDSP 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	14/46 (30%)
		HLH	505..570	CDD:238036	23/64 (36%)
Srebf2	NP_150087.1	Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956	1..50
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..133		14/81 (17%)
		Interaction with LMNA. /evidence=ECO:0000269|PubMed:11929849	226..480		65/325 (20%)
		HLH	320..370	CDD:278439	22/58 (38%)
		Leucine-zipper	369..390		6/23 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940