DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mitf and Srebf1

DIOPT Version :9

Sequence 1:	NP_001245436.1	Gene:	Mitf / 3885647	FlyBaseID:	FBgn0263112	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_035610.1	Gene:	Srebf1 / 20787	MGIID:	107606	Length:	1134	Species:	Mus musculus

Alignment Length:	567	Identity:	116/567 - (20%)
Similarity:	196/567 - (34%)	Gaps:	163/567 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 QQMMIQQQTLDTA----MDPKMHLLFGSGQ---GLMESEFI--DSGSTSACGSGSSSLEQMSQLV 247
            :|.:.:...||||    ::..:.|:.....   ||.::.:.  ::|.|.....|::|.|..|...
Mouse    12 EQTLAEMCELDTAVLNDIEDMLQLINNQDSDFPGLFDAPYAGGETGDTGPSSPGANSPESFSSAS 76

  Fly   248 QMDNLIDSSSGAKL------KVPLQSIGVDVPPQVLQVST---VLENPTRYHVIQKQKNQVR--Q 301
            ...:|.....|.|:      ..|.....:.:.|.|...|.   :.|.|....::|....|..  .
Mouse    77 LASSLEAFLGGPKVTPAPLSPPPSAPAALKMYPSVSPFSPGPGIKEEPVPLTILQPAAPQPSPGT 141

  Fly   302 YLSESF-KPSMWGSHTSEIKLAN-NSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIMP- 363
            .|..|| .|.:..|....:..:: .|..:|.|..::.|.....||           ..|..::|
Mouse   142 LLPPSFPAPPVQLSPAPVLGYSSLPSGFSGTLPGNTQQPPSSLPL-----------APAPGVLPT 195

  Fly   364 -----------SDDAMPISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANS 417
                       |...:|.|....:......:..: |.||:|:                 ..||:|
Mouse   196 PALHTQVQSLASQQPLPASAAPRTNTVTSQVQQV-PVVLQPH-----------------FIKADS 242

  Fly   418 -SLSSTRSSSG-IVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDKN 480
             .|::.::.:| .|.:..||:.:......:.|:...||......:.|..:..|.|
Mouse   243 LLLTAVKTDAGATVKTAGISTLAPGTAVQAGPLQTLVSGGTILATVPLVVDTDKL---------- 297

  Fly   481 FNSELSIKQEPQNLTDAEMNAL--AKDR-QKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFY 542
                      |.:...|...||  |:.| :|:..||.||:|.|.:|||:|.||..|: .|::|
Mouse   298 ----------PIHRLAAGSKALGSAQSRGEKRTAHNAIEKRYRSSINDKIVELKDLV-VGTEA-- 349

  Fly   543 EVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGIL 607
                  :.||..:|:.::|||:.|:|.     ..:|:|..:.|::......:|:|.....|.|
Mouse   350 ------KLNKSAVLRKAIDYIRFLQHS-----NQKLKQENLTLRSAHKSKSLKDLVSACGSGG-- 401

  Fly   608 LSENHLTSLSAPTQPYLKSFSLSPTASRSRRSLFDQPVEKKIQVIDGADGNM-GMNQVDEFMEDC 671
                                                          |.|.:| ||.  .|.:|..
Mouse   402 ----------------------------------------------GTDVSMEGMK--PEVVETL 418

  Fly   672 KYAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSFEPKNFSEADESLF 718
            .      .|...:.|..||:|.|..|:..:||..:    ||.|...|
Mouse   419 T------PPPSDAGSPSQSSPLSFGSRASSSGGSD----SEPDSPAF 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	11/44 (25%)
Mitf	NP_001245436.1	HLH	505..570	CDD:238036	25/65 (38%)
Srebf1	NP_035610.1	Transcriptional activation (acidic). /evidence=ECO:0000250\|UniProtKB:P36956	1..60		9/47 (19%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P36956	27..35		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..73		6/26 (23%)
		ERbeta_N	114..210	CDD:289279	19/106 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..149		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..195		6/35 (17%)
		Interaction with LMNA. /evidence=ECO:0000269\|PubMed:11929849	227..487		75/341 (22%)
		HLH	315..372	CDD:238036	25/70 (36%)
		Leucine-zipper	367..388		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..468		14/51 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940