Protein Alignment Mitf and tfe3a

DIOPT Version :9

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_571923.2
• Gene: tfe3a / 114834
• ZFINID: ZDB-GENE-010919-2
• Length: 539
• Species: Danio rerio
• Alignment Length: 674
• Identity: 193/674 - (28%)
• Similarity: 278/674 - (41%)
• Gaps: 214/674 - (31%)

  Fly    87 GEEPPTTSF-----ADNIDKACPLPVLRSSDCDCVPLCMTNIRVSVGIDKDLEMILEMDPSIVDL 146
            |.|.|.|.:     |::::.....|:|..|                ||..|:|:     .|:
Zfish    23 GHERPQTVYVILDSAESVNLISVEPLLPES----------------GIVADIEV-----ESV--- 63

  Fly   147 GDISIDETAEPRIVGLPPLSGGPTFKTATP--------TSRTQLKLQLQREQ---QQQMMIQQQT 200
              .|.|..|...:.|.|....| :..:|.|        |||..::.:|.|:|   |::...|:|
Zfish    64 --FSADSDAFYELKGQPITPSG-SLTSADPVTPTGSVMTSRVLMRQELMRQQAQDQERREAQKQ- 124

  Fly   201 LDTAMDPKMHLLFGSGQGLMESEFIDSGSTSACGSGSSSLEQMSQLVQMDNLIDSSSGAKLKVPL 265
                                                :||.:|        .|.||:....:...|
Zfish   125 ------------------------------------ASSAQQ--------RLTDSTPAISVASNL 145

  Fly   266 QSIGVDVPPQVLQVSTVLENPTRYHVIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGN 330
            .:....||.:||:|.|.|||||:||:.|.|:.||:|||          |||...|:|:.:.:|..
Zfish   146 PAKPTQVPVEVLKVQTHLENPTKYHIQQAQRQQVKQYL----------SHTLGNKIASQTLATSP 200

  Fly   331 LQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAMPISP-----FGGSFVRCDDINPIEPTV 390
            ....|                     ||..:.|:..:.|.||     .|.:....:|:  |:..:
Zfish   201 PPQPS---------------------SAPELAPAASSTPSSPLAVLSLGSNKEEIEDV--IDDII 242

  Fly   391 LRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSV 455
                     ..|::.....:.|..:...|.||...||  |.:.:.|:    |..:||      ::
Zfish   243 ---------SLESSLNDEFMTLIDSGLQLPSTLPVSG--NLLDVYSS----QGMAAP------TI 286

  Fly   456 ATSVSEPDDIFDDILQNDSFNFDKNFNSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRR 520
            ..|.|.|.|     |||              :|:|   ::|||..|:.|:||||||||:||||||
Zfish   287 TVSNSCPAD-----LQN--------------VKRE---MSDAEAKAIMKERQKKDNHNLIERRRR 329

  Fly   521 FNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVEL 585
            ||.||||||||.|:||.||.      ::|.|||||||:|||||:.|:.|..|.::.|.||:::|.
Zfish   330 FNTNDRIKELGALIPKSSDP------ELRWNKGTILKASVDYIRKLQKEQQRSKEMETRQKKLEH 388

  Fly   586 QNRKLMSRIKELEMQAKSHG---------------ILLSENHLTSLS----APTQPYLKSFSLSP 631
            .||.||.||:||||||:.||               :.|..|..|.||    :.||....||...|
Zfish   389 ANRSLMLRIQELEMQARLHGLSSSQLSDSLTQTQTLTLEHNPNTDLSKTLLSITQTTPSSFLSPP 453

  Fly   632 TASRSRRSLFDQPVEKKIQVIDGAD------------GNMGMNQVDEFMED--CKYAVQGGDPML 682
            :::.|.......|:|.........|            .:||:.  |..|:|  ....|.|.||:|
Zfish   454 SSTSSVGGTVTSPLELGTLSFGELDDHTASVFSPALMADMGLG--DILMDDSGALSPVGGADPLL 516

  Fly   683 SSHSHMQSAPQSPSSKTLNSGSFE 706
            |:    .|...|.:|...:|.|.|
Zfish   517 SA----VSPGASKTSSRRSSFSME 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	20/38 (53%)
		HLH	505..570	CDD:238036	43/64 (67%)
tfe3a	NP_571923.2	MITF_TFEB_C_3_N	101..238	CDD:292573	49/214 (23%)
		HLH	314..374	CDD:238036	44/65 (68%)
		DUF3371	402..538	CDD:288684	36/141 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593390
Domainoid	1	1.000	85	1.000	Domainoid score	I8110
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4340
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1211990at2759
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		otm24979
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45776
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X566
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.000