DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mitf and tfec

DIOPT Version :9

Sequence 1:	NP_001245436.1	Gene:	Mitf / 3885647	FlyBaseID:	FBgn0263112	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_002935013.2	Gene:	tfec / 100487610	XenbaseID:	XB-GENE-986001	Length:	375	Species:	Xenopus tropicalis

Alignment Length:	464	Identity:	135/464 - (29%)
Similarity:	201/464 - (43%)	Gaps:	130/464 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 QVSTVLENPTRYHVIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICD 342
            :|...|||||:||:.|.|:.||:|||:                 ..|..||..|..|
Frog    11 EVQAHLENPTKYHLQQSQRQQVKQYLN-----------------LGNKFSTQTLSYS-------- 50

  Fly   343 PLERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRCDDINPIEPTVLRP---NSHGAGEPEN- 403
                                        .|           :.|:||.:.|   |.|.:.:.:|
Frog    51 ----------------------------HP-----------HAIQPTGIVPTLRNGHMSPDTDND 76

  Fly   404 -----AHRTAQLGLSKANS---------SLSSTRSSSGIVNSIRISSTSSS-LQSTSAPISPSVS 453
                 ..:...||:::.|.         ||.|:.:..|      ::.|..: |.|::.|:|.|:.
Frog    77 TTDNPITKLMPLGVNRENEMEEVIDDIISLESSFNDDG------LNCTEPTLLMSSNLPLSSSIL 135

  Fly   454 SVATSVSEPDDIFDDILQNDSFNFDKNFNSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERR 518
            .:..|.           |:.......|....|.:|:|   .||.:..|:||:||||||||:||||
Frog   136 DLYNSD-----------QSSDMGLSNNACPSLGVKRE---ATDTDNRAMAKERQKKDNHNLIERR 186

  Fly   519 RRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQV 583
            ||:|||.||||||||:||.:|.      |:|.|||||||:||:|||.|:.|..:.|:.|.||:::
Frog   187 RRYNINYRIKELGTLIPKSNDP------DMRWNKGTILKASVEYIKWLQKEQQKGRELEHRQKKL 245

  Fly   584 ELQNRKLMSRIKELEMQAKSHGI---LLSENHLTSLSAPTQPYLKSFSLS-----PTASRSRRSL 640
            |..||:|:.||:|||:||::||:   .|....:.|.....|.|.:..|..     |.:......|
Frog   246 EQANRRLLLRIQELEIQARAHGLPMPTLCTVEIASQVIKQQTYGEDMSQDFASQLPVSIGQTADL 310

  Fly   641 FDQPVEKKIQVIDGADGNMGMNQVDEFMEDCKYAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSF 705
            .|........:....|.:......::.:|:  .:..|.||.||:           :|..|:.||.
Frog   311 CDVSTSFSDPLSHFTDLSFSAALKEQMLEE--MSPYGADPFLSA-----------TSPDLSKGSS 362

  Fly   706 EPKNFSEAD 714
            ...:||..|
Frog   363 RRSSFSTDD 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	15/32 (47%)
Mitf	NP_001245436.1	HLH	505..570	CDD:238036	43/64 (67%)
tfec	XP_002935013.2	MITF_TFEB_C_3_N	<12..101	CDD:374248	31/152 (20%)
		bHLHzip_TFEC	172..256	CDD:381495	53/89 (60%)
		DUF3371	261..372	CDD:371761	26/124 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8049
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3648
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1211990at2759
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		otm48159
Panther	1	1.100	-	-	O	PTHR45776
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X566
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.070