Protein Alignment Mitf and tfec

DIOPT Version :10

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_002935013.2
• Gene: tfec / 100487610
• XenbaseID: XB-GENE-986001
• Length: 375
• Species: Xenopus tropicalis
• Alignment Length: 464
• Identity: 135/464 - (29%)
• Similarity: 201/464 - (43%)
• Gaps: 130/464 - (28%)

  Fly   278 QVSTVLENPTRYHVIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICD 342
            :|...|||||:||:.|.|:.||:|||:                 ..|..||..|..|
 Frog    11 EVQAHLENPTKYHLQQSQRQQVKQYLN-----------------LGNKFSTQTLSYS-------- 50

  Fly   343 PLERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRCDDINPIEPTVLRP---NSHGAGEPEN- 403
                                        .|           :.|:||.:.|   |.|.:.:.:|
 Frog    51 ----------------------------HP-----------HAIQPTGIVPTLRNGHMSPDTDND 76

  Fly   404 -----AHRTAQLGLSKANS---------SLSSTRSSSGIVNSIRISSTSSS-LQSTSAPISPSVS 453
                 ..:...||:::.|.         ||.|:.:..|      ::.|..: |.|::.|:|.|:.
 Frog    77 TTDNPITKLMPLGVNRENEMEEVIDDIISLESSFNDDG------LNCTEPTLLMSSNLPLSSSIL 135

  Fly   454 SVATSVSEPDDIFDDILQNDSFNFDKNFNSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERR 518
            .:..|.           |:.......|....|.:|:|   .||.:..|:||:||||||||:||||
 Frog   136 DLYNSD-----------QSSDMGLSNNACPSLGVKRE---ATDTDNRAMAKERQKKDNHNLIERR 186

  Fly   519 RRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQV 583
            ||:|||.||||||||:||.:|.      |:|.|||||||:||:|||.|:.|..:.|:.|.||:::
 Frog   187 RRYNINYRIKELGTLIPKSNDP------DMRWNKGTILKASVEYIKWLQKEQQKGRELEHRQKKL 245

  Fly   584 ELQNRKLMSRIKELEMQAKSHGI---LLSENHLTSLSAPTQPYLKSFSLS-----PTASRSRRSL 640
            |..||:|:.||:|||:||::||:   .|....:.|.....|.|.:..|..     |.:......|
 Frog   246 EQANRRLLLRIQELEIQARAHGLPMPTLCTVEIASQVIKQQTYGEDMSQDFASQLPVSIGQTADL 310

  Fly   641 FDQPVEKKIQVIDGADGNMGMNQVDEFMEDCKYAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSF 705
            .|........:....|.:......::.:|:  .:..|.||.||:           :|..|:.||.
 Frog   311 CDVSTSFSDPLSHFTDLSFSAALKEQMLEE--MSPYGADPFLSA-----------TSPDLSKGSS 362

  Fly   706 EPKNFSEAD 714
            ...:||..|
 Frog   363 RRSSFSTDD 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:464952	15/32 (47%)
		bHLHzip_MITF_like	504..577	CDD:381403	46/72 (64%)
tfec	XP_002935013.2	MITF_TFEB_C_3_N	<11..101	CDD:464952	31/153 (20%)
		bHLHzip_TFEC	172..256	CDD:381495	53/89 (60%)
		DUF3371	261..372	CDD:463372	26/124 (21%)