DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mitf and srebf2

DIOPT Version :9

Sequence 1:NP_001245436.1 Gene:Mitf / 3885647 FlyBaseID:FBgn0263112 Length:837 Species:Drosophila melanogaster
Sequence 2:XP_012816036.1 Gene:srebf2 / 100144677 XenbaseID:XB-GENE-1011360 Length:1096 Species:Xenopus tropicalis


Alignment Length:621 Identity:117/621 - (18%)
Similarity:213/621 - (34%) Gaps:243/621 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 LCMTNIRVSVGIDKDL------EMILEMDPSIVDLGDI------------SIDETAEPRIVGLPP 164
            |.|.|:.....:..:|      ||:..:...:.|..|:            :..|||.|:.....|
 Frog     3 LNMENMETLTELGDELTLGDIDEMLQFVSNQVGDFPDLFEEQLCQSYQGNNAMETALPKAYNQAP 67

  Fly   165 LSGGPTFKTATPTSRT------------------QLKLQLQREQQQQMMIQQQTLDTAMDPKMHL 211
            ..   .:.|:||..:|                  |.:..:|...|.|  :||||:          
 Frog    68 QQ---PYTTSTPQPQTLPVKAPSQVTPQRTAPLLQPRPVIQSSPQPQ--LQQQTV---------- 117

  Fly   212 LFGSGQGLMESEFIDSGSTSACGSGSSSLEQMSQLVQMDNLIDSSSGAKLKV---PLQSIGVDVP 273
                   ::...|              |....::::|.. ||..::....:|   |:||:   :.
 Frog   118 -------MLTPNF--------------STAPQTRIIQQP-LIYQNAATSFQVLQPPVQSL---MT 157

  Fly   274 PQVLQVSTVLENPTRYHVIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQK 338
            .|.:|..|:.:        |.|..|.::.|::                    |:.|.:|..:   
 Frog   158 TQQMQPVTIQQ--------QVQTVQAQRVLTQ--------------------AANGTIQTLT--- 191

  Fly   339 GICDPLERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPEN 403
                           .|.:.:.:.|....:|:.              ::|.:::..|        
 Frog   192 ---------------PATTVQTVTPQVQQVPVL--------------VQPQIIKTES-------- 219

  Fly   404 AHRTAQLGLSKANSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDD 468
                ..|...||:.|...|     .:.:..|::.::.:|:|:..:...:.|..|.::....:.. 
 Frog   220 ----LVLTAVKADGSPVMT-----TMQNPAITTLATPIQTTALQVPTLMGSNGTILTTMPVMMG- 274

  Fly   469 ILQNDSFNFDKNFNSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTL 533
                         ..::.|||.|.:|...|   :.|:.:::..||:||:|.|.:|||:|.||..|
 Frog   275 -------------QEKMPIKQVPGSLKQPE---VPKEGERRTTHNIIEKRYRSSINDKIIELKDL 323

  Fly   534 LPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELE 598
            : .|:||        :.:|..:||.::||||.|:....:|||..:   .::|.|:|         
 Frog   324 V-MGTDA--------KMHKSGVLKKAIDYIKYLQQVNQKLRQENM---ALKLANQK--------- 367

  Fly   599 MQAKSHGILLSENHLTSLSAPTQPYLKSFSLSPTASRSRRSLFDQPVEKKIQVIDGADGNMGMNQ 663
                                  ..|||...||        ||              .|.::|| :
 Frog   368 ----------------------NKYLKGIDLS--------SL--------------VDTSIGM-K 387

  Fly   664 VDEFMEDCKY----AVQGGDPMLSSHSHMQSAPQSP 695
            :|||.::...    |...|.|.:.|...:.|.|.||
 Frog   388 MDEFNQNILMMSPPASDSGSPAVFSPYSVDSEPGSP 423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MitfNP_001245436.1 MITF_TFEB_C_3_N <272..>311 CDD:292573 7/38 (18%)
HLH 505..570 CDD:238036 24/64 (38%)
srebf2XP_012816036.1 bHLHzip_SREBP2 293..369 CDD:381492 31/118 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1708
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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