DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34002 and CRISPLD2

DIOPT Version :9

Sequence 1:	NP_001034029.2	Gene:	CG34002 / 3885644	FlyBaseID:	FBgn0054002	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_113664.1	Gene:	CRISPLD2 / 83716	HGNCID:	25248	Length:	497	Species:	Homo sapiens

Alignment Length:	375	Identity:	80/375 - (21%)
Similarity:	124/375 - (33%)	Gaps:	134/375 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GPCVATGLLLLFGLNLVFLLPE--------TNYCHLKNCPADKKLPHIGCNNSGSWSPKCGKDPK 60
            |..:..|||.|...:..:|||.        :.|.|               |.|.|...:.
Human     6 GGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQH---------------NESHSRVRRA----- 50

  Fly    61 IIDVPKHIKKLILNHHNTYRDIVAGGQMHRLPIAARMLKLKWDHELALLATILVKRC--DLQPTD 123
               :|:..|:.||..||..|     ||:.  |.|:.|..:.||.||...|.....:|  :..||.
Human    51 ---IPREDKEEILMLHNKLR-----GQVQ--PQASNMEYMTWDDELEKSAAAWASQCIWEHGPTS 105

  Fly   124 HCISTEE--------FSSPSYHAVYNKFKAKEDTFRIVRSQLNAWYDQ-----YKHVSSSSLIDG 175
            ..:|..:        :.||.:|                   :.:|||:     |.:.|..:....
Human   106 LLVSIGQNLGAHWGRYRSPGFH-------------------VQSWYDEVKDYTYPYPSECNPWCP 151

  Fly   176 LSTAKKEIGHFLRMIVGPSNRLGCAIASIEK-GGWTHQW-----LACLYSC-------SPQKNSL 227
            ...:.....|:.:::...:|::|||:.:..| ..|...|     ..|.||.       :|.||
Human   152 ERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKN-- 214

  Fly   228 LYEYSGKPGVYCTTGINGKFQ-NLCN-----------------DTEPVKDCMH----------SE 264
                 |:|...|.....|..: |||.                 :|.|:.:..|          ::
Human   215 -----GRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPIPEENHVWLQPRVMRPTK 274

  Fly   265 LFQTITANDTTSLIR-----------SMLNRQTQPRTFGWLWNWGKKIWG 303
            ..:|...|..|.::|           |..||...|.  |.| |...||:|
Human   275 PKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPA--GCL-NHKAKIFG 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34002	NP_001034029.2	SCP_euk	69..219	CDD:240180	37/170 (22%)
CRISPLD2	NP_113664.1	SCP_euk	56..201	CDD:240180	37/170 (22%)
		LCCL	286..370	CDD:128866	11/39 (28%)
		LCCL	387..479	CDD:128866
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151107
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1528782at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750