DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33966 and Sec14l1

DIOPT Version :9

Sequence 1:	NP_001033984.1	Gene:	CG33966 / 3885642	FlyBaseID:	FBgn0053966	Length:	310	Species:	Drosophila melanogaster
Sequence 2:	NP_083053.2	Gene:	Sec14l1 / 74136	MGIID:	1921386	Length:	719	Species:	Mus musculus

Alignment Length:	344	Identity:	74/344 - (21%)
Similarity:	132/344 - (38%)	Gaps:	89/344 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TAIENLNEVP-NKLDDD----------------IAALRDWIKQQPHLKARTDDQFLVNFLRGCKF 61
            ||.|.:...| :|||.|                :..||.|: |:.|......|:.::.|||...|
Mouse   226 TASEPVVGTPDDKLDADYIKRYLGDLTPLQESCLIRLRQWL-QETHKGKIPKDEHILRFLRARDF 289

  Fly    62 SLE------------RTKSKIDRFYTLRTKYP-----EFYLG--HNVDVD-KALEIFRLGTIVI- 105
            :::            |.:.::|  |.|.|..|     ::|.|  |:.|.| :.|.:.|||.:..
Mouse   290 NIDKAREIMCQSLTWRKQHQVD--YILDTWTPPQVLLDYYAGGWHHHDKDGRPLYVLRLGQMDTK 352

  Fly   106 -LPRPLNDNGPRLALLRMACYDPSKYTLQEVNRAAGLMQQIMLDEDDVAIVNGLIS----ILDLS 165
             |.|.|.:.    ||||        |.| .:|. .||.:    .|::..:....||    ::||.
Mouse   353 GLVRALGEE----ALLR--------YVL-SINE-EGLRR----CEENTKVFGRPISSWTCLVDLE 399

  Fly   166 NVTTGHFLQMSPSFAKKMTVFQEEALPLRPQGIHFINTPNGFDTIFNMIKPMMSKKQQGRLYVH- 229
            .:...|..:.......::....|...|.....:..:..|..|..::.::.|.:....:.:..::
Mouse   400 GLNMRHLWRPGVKALLRIIEVVEANYPETLGRLLILRAPRVFPVLWTLVSPFIDDNTRRKFLIYA 464

  Fly   230 GSKWE---ALYNQIPKQYLPVEYGG-------ENGSIPELLQQWEQRILAYRNYWEEEKNYGTDE 284
            |:.::   .|.:.|.|:.:|....|       |.|.:|:.|         ||...|.|     :|
Mouse   465 GNDYQGPGGLLDYIDKEIIPDFLSGECMCDVPEGGLVPKSL---------YRTAEELE-----NE 515

  Fly   285 SLRVGQPVDFESLFGLQGS 303
            .|::.....::|....:|:
Mouse   516 DLKLWTETIYQSASVFKGA 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33966	NP_001033984.1	CRAL_TRIO_N	30..72	CDD:215024	11/53 (21%)
CG33966	NP_001033984.1	SEC14	96..252	CDD:238099	32/172 (19%)
Sec14l1	NP_083053.2	Required for interaction and inhibitory function toward DDX58. /evidence=ECO:0000250\|UniProtKB:Q92503	1..510		68/313 (22%)
		PRELI	17..173	CDD:282550
		CRAL_TRIO_N	256..301	CDD:215024	10/45 (22%)
		CRAL_TRIO	326..490	CDD:279044	37/181 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810