DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33966 and CLVS1

DIOPT Version :9

Sequence 1:	NP_001033984.1	Gene:	CG33966 / 3885642	FlyBaseID:	FBgn0053966	Length:	310	Species:	Drosophila melanogaster
Sequence 2:	NP_775790.1	Gene:	CLVS1 / 157807	HGNCID:	23139	Length:	354	Species:	Homo sapiens

Alignment Length:	288	Identity:	84/288 - (29%)
Similarity:	146/288 - (50%)	Gaps:	33/288 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSPE-LQKTAIENLNEVPNKLDDDIAALRDWIKQQPHLK-ARTDDQFLVNFLRGCKFSLERTKSK 69
            |||| ::|..:| |||.|:.|..||..:||.|..:|.:. .||||.|::.|||..||      .:
Human    30 LSPETIEKARLE-LNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKF------HQ 87

  Fly    70 IDRFYTLRTKYPEFYLGHNVDVDKALEIFRLGTIVILPRPLNDN-----------GPRLALLRMA 123
            .|.|..|...:.  |...|:|:.|..:....|    :.|.|.|.           |.::.||..|
Human    88 ADAFRLLAQYFQ--YRQLNLDMFKNFKADDPG----IKRALIDGFPGVLENRDHYGRKILLLFAA 146

  Fly   124 CYDPSKYTLQEVNRAAGLMQQIMLDEDDVAIVNGLISILDLSNVTTGHFLQMSPSFAKKMTVFQE 188
            .:|.|:.:..::.||..|..::::::.::.| ||.|.|:|.||.:.....:::||..|......:
Human   147 NWDQSRNSFTDILRAILLSLEVLIEDPELQI-NGFILIIDWSNFSFKQASKLTPSILKLAIEGLQ 210

  Fly   189 EALPLRPQGIHFINTPNGFDTIFNMIKPMMSKKQQGRLYVHGSKWEALYNQIPKQYLPVEYGGEN 253
            ::.|.|..|:||:|.|.....::.:|||.:..|.:.|:::||:...:|:..|..::||.|:|
Human   211 DSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFG--- 272

  Fly   254 GSIPEL-LQQWEQRILAYRNYWEEEKNY 280
            |::|.. :..|.:.:|.  ..:.:|.:|
Human   273 GTLPPYDMGTWARTLLG--PDYSDENDY 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33966	NP_001033984.1	CRAL_TRIO_N	30..72	CDD:215024	15/42 (36%)
CG33966	NP_001033984.1	SEC14	96..252	CDD:238099	44/166 (27%)
CLVS1	NP_775790.1	CRAL_TRIO_N	51..97	CDD:215024	19/51 (37%)
		CRAL_TRIO	125..274	CDD:306996	40/152 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750