Protein Alignment CG33966 and CLVS2

DIOPT Version :10

• Sequence 1: NP_001033984.1
• Gene: CG33966 / 3885642
• FlyBaseID: FBgn0053966
• Length: 310
• Species: Drosophila melanogaster
• Sequence 2: NP_001010852.2
• Gene: CLVS2 / 134829
• HGNCID: 23046
• Length: 327
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 86/293 - (29%)
• Similarity: 150/293 - (51%)
• Gaps: 37/293 - (12%)

  Fly     7 LSPE-LQKTAIENLNEVPNKLDDDIAALRDWIKQQPHLK-ARTDDQFLVNFLRGCKFSLERTKSK 69
            |||| |:|..:| |||.|:.|..||..:||.:..:|.:. .||||.|::.|||..||
Human     8 LSPETLEKARLE-LNENPDTLHQDIQEVRDMVITRPDIGFLRTDDAFILRFLRARKF-------- 63

  Fly    70 IDRF--YTLRTKYPEFYLGHNVDVDKALEIFRLGTIVILPRPLNDN-----------GPRLALLR 121
             ..|  :.|..:|.| |...|:|:.|:.:....|    :.:.|.|.           |.::.:|.
Human    64 -HHFEAFRLLAQYFE-YRQQNLDMFKSFKATDPG----IKQALKDGFPGGLANLDHYGRKILVLF 122

  Fly   122 MACYDPSKYTLQEVNRAAGLMQQIMLDEDDVAIVNGLISILDLSNVTTGHFLQMSPSFAKKMTVF 186
            .|.:|.|:|||.::.||..|..:.|:::.::. |||.:.|:|.||.|.....:::||..:.....
Human   123 AANWDQSRYTLVDILRAILLSLEAMIEDPELQ-VNGFVLIIDWSNFTFKQASKLTPSMLRLAIEG 186

  Fly   187 QEEALPLRPQGIHFINTPNGFDTIFNMIKPMMSKKQQGRLYVHGSKWEALYNQIPKQYLPVEYGG 251
            .:::.|.|..||||:|.|.....::.:|:|.:.:|.:.|:::||:...:|:..|..:.||.|:|
Human   187 LQDSFPARFGGIHFVNQPWYIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFG- 250

  Fly   252 ENGSIPEL-LQQWEQRILAYRNYWEEEKNYGTD 283
              |.:|.. :..|.:.:|.:.  ::::..|..|
Human   251 --GMLPPYDMGTWARTLLDHE--YDDDSEYNVD 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33966	NP_001033984.1	CRAL_TRIO_N	30..72	CDD:215024	14/42 (33%)
		CRAL_TRIO	113..251	CDD:459890	41/148 (28%)
CLVS2	NP_001010852.2	CRAL_TRIO_N	29..75	CDD:215024	17/54 (31%)
		SEC14	101..251	CDD:469559	43/153 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..327