Protein Alignment Egfrap and RIN1

DIOPT Version :10

• Sequence 1: NP_001033991.1
• Gene: Egfrap / 3885637
• FlyBaseID: FBgn0053993
• Length: 421
• Species: Drosophila melanogaster
• Sequence 2: NP_004283.2
• Gene: RIN1 / 9610
• HGNCID: 18749
• Length: 783
• Species: Homo sapiens
• Alignment Length: 151
• Identity: 49/151 - (32%)
• Similarity: 68/151 - (45%)
• Gaps: 14/151 - (9%)

  Fly   234 TQRLQVELPAASKKYLRETCSANSS--PKLFPGHSALRLDNLSLAEQQELKGAAWFQAGIPREIS 296
            |..|..|.||....|.....|...:  |:. ||..      :||.|:..|....|.|.......:
Human    22 TGHLAREKPAQDPLYDVPNASGGQAGGPQR-PGRV------VSLRERLLLTRPVWLQLQANAAAA 79

  Fly   297 LEALSRQSPGAFLVRQSSTKPGCFALSLRVPP---PSPRVAHYLILRTQRGYKIKGFTKEFSSLK 358
            |..|..:.||.||||:|:|:. |.||.:|:|.   ||...:|| ||.:..|..::|....|..|.
Human    80 LHMLRTEPPGTFLVRKSNTRQ-CQALCMRLPEASGPSFVSSHY-ILESPGGVSLEGSELMFPDLV 142

  Fly   359 ALITHHSVMPELLPVPLTLPR 379
            .||..:....::|.:||.|||
Human   143 QLICAYCHTRDILLLPLQLPR 163

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfrap	NP_001033991.1	SH2	286..364	CDD:198173	29/80 (36%)
RIN1	NP_004283.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		8/31 (26%)
		SH2	58..158	CDD:472789	33/101 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..282
		Ras and 14-3-3 protein binding region	294..727
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..342
		VPS9	489..607	CDD:128469
		Ubl1_cv_Nsp3_N-like	625..705	CDD:475130
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	709..783