DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33993 and tns2a

DIOPT Version :9

Sequence 1:	NP_001033991.1	Gene:	CG33993 / 3885637	FlyBaseID:	FBgn0053993	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_001921043.3	Gene:	tns2a / 799109	ZFINID:	ZDB-GENE-090312-163	Length:	1616	Species:	Danio rerio

Alignment Length:	465	Identity:	120/465 - (25%)
Similarity:	173/465 - (37%)	Gaps:	130/465 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ISSSSASSSSSQTAETTLIETAEKSP-------ASEAAAGTVTTTSP-QHFFHHHHPPAHPHPPR 76
            |..:..::.|.||..::..||.|.:|       |...||.::.||.| ......|.||..|....
Zfish  1053 IQPNMTNAGSRQTLLSSSPETPEINPLPTTPTTAQHLAAHSLPTTPPTPQIATEHSPPLTPESES 1117

  Fly    77 QQPHPHSHSHPH-----PHPQLQRRPVEQLHLLHSHHDVQELSGQEHPHPQPGSHP-----HPHH 131
            .|  |.::..|.     |..::..:..|.:...||            |||   |.|     .|.|
Zfish  1118 TQ--PQANCSPTAATVLPTVEMVPQSTETIKPAHS------------PHP---SSPVLAESIPAH 1165

  Fly   132 LRS---PSSEEDNSPTEMNNCRRLVDKP-----------PLVKRL-TMGIGLLRGTEDSRPLMHS 181
            ::|   |.|.|.::|...::.......|           |.|... |:|..|:.|:|.|....||
Zfish  1166 MQSNGVPPSPESDAPKPASSAPASPQPPAGDHESSSSPEPSVPGFATLGRKLMLGSETSLSAGHS 1230

  Fly   182 TCGSSLTSGSGCGSTQTISDGYVNEAICEPDKYVASKFGDSCRQSL------------SAL---- 230
            ...||       .||.|..   |:.|.|.|.....|..|  |..|.            |.|
Zfish  1231 MDASS-------NSTPTFP---VSPACCTPSPPPGSYPG--CPSSSVPQPPLPEKRRPSGLPGSP 1283

  Fly   231 --ESATQRLQVELPAASKKYLRETCSANSSPKLFPGHSALRLDNLSLAEQQEL-----------K 282
              .|.|.|..:....:.:.::      ..||.:  |..|:.:..:.:..:.|:           .
Zfish  1284 NGRSGTLRASMSHQPSGQHHV------TFSPSV--GELAVPIGQVEVGVEGEIGNRVSVKFVQDS 1340

  Fly   283 GAAWFQAGIPREISLEALSRQSPGAFLVRQSSTKPGCFALSLRVPPPSPR--------------V 333
            ...|::.||.||.::.||..:.|||||:|.|::..|.:.|:|:|..|.|.              |
Zfish  1341 SRFWYKPGISREQAIAALKEREPGAFLIRDSNSFQGAYGLALKVASPPPNVNNHSSKGDPLEQLV 1405

  Fly   334 AHYLILRTQRGYKIKGFTKE--FSSLKALITHHSVMPELLPVPLTLP-----------RPPSTRS 385
            .|:||....||.||||...|  |.||.||:..||:.|..||..|.:|           :|.|..|
Zfish  1406 RHFLIETGPRGVKIKGCQNEPYFGSLSALVYQHSITPISLPCALRIPEKDPIGDVVEVQPVSNMS 1470

  Fly   386 QRS----QGA 391
            ..:    |||
Zfish  1471 TAADLLKQGA 1480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33993	NP_001033991.1	SH2	286..364	CDD:198173	36/93 (39%)
tns2a	XP_001921043.3	C1	45..91	CDD:237996
		PTPc_motif	205..325	CDD:214649
		PTEN_C2	313..440	CDD:313607
		Atrophin-1	<903..1322	CDD:331285	70/305 (23%)
		SH2_Tensin_like	1340..1455	CDD:198181	43/114 (38%)
		PTB_tensin	1479..1611	CDD:269924	2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45734
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010