DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33993 and tns1a

DIOPT Version :9

Sequence 1:	NP_001033991.1	Gene:	CG33993 / 3885637	FlyBaseID:	FBgn0053993	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_009300586.1	Gene:	tns1a / 565181	ZFINID:	ZDB-GENE-120215-32	Length:	1688	Species:	Danio rerio

Alignment Length:	536	Identity:	116/536 - (21%)
Similarity:	179/536 - (33%)	Gaps:	159/536 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MQDIRLR-------LEPQHSKATFISSSSASSSSSQTAETTLI------------------ETAE 42
            |..:|.|       |..||..|..:..|.....||:.|.|..:                  |..|
Zfish  1019 MPTVRRRTTSESQYLSSQHDSAAHVVRSPLKPVSSEFANTITMNPGGQPKEKSVHSYREAFEEME 1083

  Fly    43 KSPASEA-------------AAGTVTTTSPQHFFHHHHPPAHPHPPRQQPHPH-----------S 83
            .:|.|.|             |||.......:.....:...:......::||..           |
Zfish  1084 SAPFSSAHDNAGLSGQATLSAAGLRAQNPAEALVQQNSSDSDSSDEMEEPHGFVGTGIREGGFIS 1148

  Fly    84 HSHPHPHPQLQRRPVEQLHLLHSHHDVQELS----GQEHPHPQPGSHPHPHHLRSP--------- 135
            ..| ||:.....|||...|.......|...|    |.:...|...|.|    :|:|
Zfish  1149 PLH-HPYSPASERPVPPAHTFSPPQPVNNTSSDGFGNQRAFPSFPSEP----IRAPLFLDTFSYL 1208

  Fly   136 SSEE--------DNSPTEMNNCRRLV-----DKPPLVKRL------TMGIGLLRGTEDSRPLMHS 181
            :.:|        .:.|...|...|.|     ..|.|.:||      ..|..:......|.|   :
Zfish  1209 NPDEATVNIMGIHHVPGSPNTLHRTVATNTPPSPALQRRLGGPSSPAFGRRITTANSGSEP---T 1270

  Fly   182 TCGSSLTSGSG-CGSTQTISDGYVNEA--ICEPDKYVA--------SKFGDSCRQSLSAL----- 230
            |..|.|...|| ......:.|.:.:.|  ...||..|.        .:.|...|||:::.
Zfish  1271 TPNSPLLGRSGKFIPPSPVLDRHPSPAPVASSPDHKVLPRGQATPDERHGAQSRQSITSTVQPGH 1335

  Fly   231 ----------ESATQRLQVELPAASKKYLRETCSANSSP-----------KLFPGHSALRLDNLS 274
                      .|.:..|.:::.|.|.....|:..|:..|           .::.|...:|: |:.
Zfish  1336 ATPTFPIEQSSSPSLFLPLDIRAGSSMENSESGPADCGPTQVPPQGPAITSIYDGPPDIRI-NIK 1399

  Fly   275 LAEQQELKGAAWFQAGIPREISLEALSRQSPGAFLVRQSSTKPGCFALSLRV--PPPSPR----- 332
            ..:.   ....|::..|.||.::..|..:.||||::|.|::..|.:.|:::|  |||:.:
Zfish  1400 FVQD---TSKYWYKPEITREQAICILKDREPGAFVIRDSNSFRGAYGLAMKVASPPPTVQQNKKV 1461

  Fly   333 -------VAHYLILRTQRGYKIKGFTKE--FSSLKALITHHSVMPELLPVPLTLP-RPP------ 381
                   |.|:||..:.:|.::||...|  |..|.||:..|::.|..||..|.:| |.|
Zfish  1462 GDITNELVRHFLIETSAKGVRLKGCPNEPYFGCLSALVYQHAITPLALPCKLMIPTRDPNEEALE 1526

  Fly   382 ------STRSQRSQGA 391
                  ||.....|||
Zfish  1527 LATPTSSTMDLLKQGA 1542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33993	NP_001033991.1	SH2	286..364	CDD:198173	29/93 (31%)
tns1a	XP_009300586.1	C1	<55..88	CDD:197519
		PTPc_motif	188..>257	CDD:214649
		PTEN_C2	297..424	CDD:287393
		SH2_Tensin_like	1404..1519	CDD:198181	35/114 (31%)
		PTB_tensin	1553..1683	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45734
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010