DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33993 and by

DIOPT Version :9

Sequence 1:	NP_001033991.1	Gene:	CG33993 / 3885637	FlyBaseID:	FBgn0053993	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001163569.1	Gene:	by / 41144	FlyBaseID:	FBgn0000244	Length:	720	Species:	Drosophila melanogaster

Alignment Length:	461	Identity:	111/461 - (24%)
Similarity:	168/461 - (36%)	Gaps:	113/461 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RLRLEPQHSKATFISSSSASSSSSQTAETTLIETAEKSPASEAAAGTVTTTSPQHFFHHHHPPAH 71
            |.|:.|...:..:..|..........:..||.   .|||:|.   |..|..:....|:.:.....
  Fly   202 RARVAPAPPQRQYYPSDGYGIGLKNDSNGTLY---RKSPSSN---GKSTKYNYDFEFNLNLDDVR 260

  Fly    72 PHPPRQQPHPHSHSHPH----------PHPQLQRRPVEQ----LHLLHSHHDVQELSGQEHPHPQ 122
            |     :|.|::..:.|          |...:.||.:|:    ::.|.:.|..|:|    .|..|
  Fly   261 P-----EPTPYTTRNIHFEDLRLDQDVPDGVVNRRTMERNYHTINSLETTHKRQQL----EPLEQ 316

  Fly   123 PGSHPHPHHLR------------SPSSEEDNSPTEMNNCRRLVDKPPLVKRLTMGIGLLRGTEDS 175
            .|:....:|:.            |.|:.:..||........:....|:....|..:        |
  Fly   317 LGAVYGQNHMEETLTRTRRDLSASTSTSKSTSPLPAIGVPAIAPASPIYATSTKRV--------S 373

  Fly   176 RPLMHSTCGSSLTSGSGCGSTQTISDGYVNEAICEPDKYVASK--FGDSCRQSLSALESATQRLQ 238
            .|   :|.|....:.|.....:|            |...|..:  ||.|...|.| |...||
  Fly   374 NP---NTNGQQQMTPSPTSRPET------------PAFPVTPRTPFGASSSSSAS-LAPTTQ--- 419

  Fly   239 VELPAASKKYLRETCSANSSPKLFPGHSALRL--DNLSLAEQQELKGAAWFQAGIPREISLEALS 301
              ||..|   :.:|......|   |....|.:  |::..|..   ....|::..:.||.::..|:
  Fly   420 --LPPES---IYQTGPRRGVP---PALQPLEVSADSVQFARS---SSQFWYKPNLTREDAIALLA 473

  Fly   302 RQSPGAFLVRQSSTKPGCFALSLRV--PPPSPR--VAHYLILRTQRGYKIKGFTKE--FSSLKAL 360
            ...||.||||.|:|....:.|.:||  |||..:  |.|:||..|:.|..:||...|  |:||.||
  Fly   474 SAQPGTFLVRDSTTYKDSYGLVVRVSQPPPGSQELVRHFLIEPTKGGVHLKGCDDEPVFTSLSAL 538

  Fly   361 ITHHSVMPELLPVPLTLPR----PP---STRSQRSQGAYAGG--------------TGNGG---A 401
            :..||:....||..|.||.    ||   :|.:|:...|:...              |||..   |
  Fly   539 VFEHSISQLALPCLLRLPDRDIVPPVRATTPAQQHLLAHGAATNVLWLYSCDTESLTGNEAIRKA 603

  Fly   402 DFEMYG 407
            ..:|||
  Fly   604 IRQMYG 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33993	NP_001033991.1	SH2	286..364	CDD:198173	32/83 (39%)
by	NP_001163569.1	SH2_Tensin_like	454..559	CDD:198181	39/104 (38%)
by	NP_001163569.1	PTB_tensin	578..711	CDD:269924	7/32 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466358
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45734
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940