DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33993 and Tns3

DIOPT Version :9

Sequence 1:	NP_001033991.1	Gene:	CG33993 / 3885637	FlyBaseID:	FBgn0053993	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_008768557.1	Gene:	Tns3 / 360980	RGDID:	1564174	Length:	1562	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	112/458 - (24%)
Similarity:	161/458 - (35%)	Gaps:	138/458 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIMQDIRLRLEPQHSKAT---------------FISSSSASSS-------SSQTAETTLIETAEK 43
            :|...:.:...|..||.|               |.:|.:.||:       |..:||....|::.|
  Rat  1006 IISHTVGMSESPLGSKPTLLRADMPATPNFQQVFAASCTVSSNGPGQRRESPPSAERQWAESSPK 1070

  Fly    44 SP--------ASEAAAGTVTTTSPQHFF--HHHHPPAHP--HPPRQQPHPHSHSHPHPHPQLQRR 96
            |.        .||:..||       |.|  ...:.|..|  .....|...|||.......|....
  Rat  1071 STLTLLGNNRPSESPLGT-------HEFCSSGKNSPGLPCFQSSELQASFHSHELSMSESQDAMP 1128

  Fly    97 PV-EQLHL-----------LHSHHDVQELSGQEH-PHPQPGSH------------PHPHHLRSPS 136
            |. .|..|           |....|...|....| |.|.||:.            .|.....||.
  Rat  1129 PAGSQTFLGFNTVTTVTSGLPPSEDAGTLLVNSHGPSPVPGTPLTTTGAADNGFLSHNFLTVSPG 1193

  Fly   137 SEEDNSPTEMNNCRRLVDKPPLVKRLTMGIGLLRGTEDSRPLMHSTCGSSLTSGSGCGSTQTISD 201
            :...:||...|....|..:|||.::       .|.:|..|.|...:..||..|....|||.:|..
  Rat  1194 ASSHHSPGLQNQGISLPGQPPLPEK-------KRTSEGDRSLGSVSPSSSGFSSPHSGSTMSIPF 1251

  Fly   202 GYVNEAICEPDKYVASKFGDSCRQSLSALESATQRLQVELPAASKKYLRETCSANSSPKLFPGHS 266
            ..|....|:|.: ||:...||....|..:                |::::|
  Rat  1252 PNVLPDFCKPSE-VATPLPDSPNDKLVIV----------------KFVQDT-------------- 1285

  Fly   267 ALRLDNLSLAEQQELKGAAWFQAGIPREISLEALSRQSPGAFLVRQSSTKPGCFALSLRV--PPP 329
                            ...|::|.|.||.::..|..::||:|:||.|.:..|.:.|:::|  |||
  Rat  1286 ----------------SKFWYKADISREQAIAMLKDKAPGSFIVRDSHSFRGAYGLAMKVATPPP 1334

  Fly   330 S-------------PRVAHYLILRTQRGYKIKGFTKE--FSSLKALITHHSVMPELLPVPLTLP- 378
            |             ..|.|:||..|.:|.::||.:.|  |.||.||:..||:.|..||..|.:|
  Rat  1335 SVLHLNKKAGDLSNELVRHFLIECTPKGVRLKGCSNEPYFGSLTALVCQHSITPLALPCKLLIPE 1399

  Fly   379 RPP 381
            |.|
  Rat  1400 RDP 1402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33993	NP_001033991.1	SH2	286..364	CDD:198173	33/94 (35%)
Tns3	XP_008768557.1	C1	39..85	CDD:237996
		PTPc_DSPc	190..304	CDD:214469
		PTEN_C2	291..417	CDD:287393
		SH2_Tensin_like	1285..1401	CDD:198181	41/145 (28%)
		PTB_tensin	1425..1556	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45734
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010