Protein Alignment Egfrap and Fer

DIOPT Version :10

• Sequence 1: NP_001033991.1
• Gene: Egfrap / 3885637
• FlyBaseID: FBgn0053993
• Length: 421
• Species: Drosophila melanogaster
• Sequence 2: NP_001382687.1
• Gene: Fer / 301737
• RGDID: 1306273
• Length: 823
• Species: Rattus norvegicus
• Alignment Length: 497
• Identity: 107/497 - (21%)
• Similarity: 168/497 - (33%)
• Gaps: 119/497 - (23%)

  Fly     6 IRLRLEPQHSKATFISSSSASSSSSQ------TAETTLIETAEKSPASEAAAGTV-TTTSPQHFF 63
            |..::|.:..|.|........||..|      :|:....|...|...:|.|.... ..|...|..
  Rat   117 IHQQIEAEMIKVTKTELEKLKSSYRQLIKEMNSAKEKYKEALAKGKETEKAKERCDKATMKLHML 181

  Fly    64 HHHHPPAHPHPPRQQPHPHSHSHPHPHPQLQRRPVEQL-------------------HLLHSHHD 109
            |:.:..|.......|...:..:.|.....:|:...|.:                   .:::.|.:
  Rat   182 HNQYVLALKGAQLHQSQYYDTTLPLLLDSVQKMQEEMIKALKGIFDEYSEITSLVTEEIVNVHKE 246

  Fly   110 VQELSGQEHPHPQPGSHPHPHHLRSPSSEEDNSPTEMNNCRRLVDKPPLVKRLTMGIGLLRGTED 174
            :|....|..|..:.......|...:...:|....|.:     |.:...|.....|...|   |.|
  Rat   247 IQMSVDQIDPSTEYNDFIDVHRTTAAKEQEIEFDTSL-----LEENENLQANEIMWNNL---TAD 303

  Fly   175 SRPLMHSTCGSSLTSGSGCGSTQTISDGYVNEAICEPDKYVASKFGDSC------------RQSL 227
            |..:|..|....||      .||.:. .:...|:.|.:|.: .:..::|            :|:|
  Rat   304 SLQVMLKTLAEELT------QTQQML-LHKEAAVLELEKRI-EESSETCAKKSDIVLLLGQKQAL 360

  Fly   228 SALESATQRLQVELP--AASKKYLRETCSAN---------------------------------- 256
            ..|:.:.|:|:....  ||.|:.|.:....|
  Rat   361 EELKQSVQQLRCTEAKCAAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIR 425

  Fly   257 -------SSPKLFPGHSALRLDNLSLAEQQELKGAAWFQAGIPREISLEALSRQSPGAFLVRQSS 314
                   .|||...|.|....|.:|:.| :.|....|:...|||..:.|.|.:|  |.||||:|.
  Rat   426 HSIAGIIKSPKSVLGSSTQLSDVISVGE-KPLAEHDWYHGAIPRIEAQELLKQQ--GDFLVRESH 487

  Fly   315 TKPGCFALSLRVPPPSPRVAHYLILRTQRGYKIKGFTKEFSSLKALITHH----SVMPELLPVPL 375
            .|||.:.||:.   ...:..|::|......|:.:|  ..||::..||.||    .|:.:...|.|
  Rat   488 GKPGEYVLSVY---SDGQRRHFIIQFVDNLYRFEG--TGFSNIPQLIDHHFNTKQVITKKSGVVL 547

  Fly   376 TLPRPPSTR-----SQRSQGAYAGGTGNGGADFEMY-GSLND 411
            ..|.|...:     ...|.|... |.||.|   |:| |:|.|
  Rat   548 LNPIPKDKKWVLNHEDVSLGELL-GKGNFG---EVYKGTLKD 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfrap	NP_001033991.1	SH2	286..364	CDD:198173	26/77 (34%)
Fer	NP_001382687.1	Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250	1..300		30/187 (16%)
		F-BAR_Fer	5..238	CDD:153370	20/120 (17%)
		SH2_Fps_family	454..539	CDD:198224	29/91 (32%)
		Protein Kinases, catalytic domain	567..817	CDD:473864	10/23 (43%)