DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33993 and Tns1

DIOPT Version :9

Sequence 1:	NP_001033991.1	Gene:	CG33993 / 3885637	FlyBaseID:	FBgn0053993	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_038939258.1	Gene:	Tns1 / 301509	RGDID:	68427	Length:	1937	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	122/494 - (24%)
Similarity:	167/494 - (33%)	Gaps:	122/494 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PQHSKATFISSSSASSSSSQTAETTLIETAEKSP-ASEAAAGTVTTTSPQHFFHHHHP----PAH 71
            |.:|...|  |||..|..........:.....|| |.....||.|..||.......:|    |..
  Rat  1348 PDYSLQPF--SSSPESQGQPHFSAASVHMVPGSPQARHRTVGTNTPPSPGFGRRAINPTMAAPGS 1410

  Fly    72 PHPPRQQ---------------PHPHSHSHPHPHPQLQRRPVEQLHLLHSHHDVQELSGQEHPHP 121
            |....:|               .||.|.:.....|.|.|.||....:...|..|....|.    |
  Rat  1411 PSLSHRQVMGPSGPGFHGNVVSGHPTSATVAPGSPSLGRHPVGSHQVPGLHSGVVTTPGS----P 1471

  Fly   122 QPGSHPHPHHLRSPSSEEDN------SPT---EMNNCRRLVDKPPLVKRLTMGIGLLRGTEDSRP 177
            ..|.||..|.....||...|      ||:   .:.....:|...|.:.| .:..|.....||.||
  Rat  1472 SLGRHPGAHQGNLVSSLHGNAVISPGSPSLGRHLGGSGSVVPGSPSLDR-HVAYGGYSTPEDRRP 1535

  Fly   178 LMHSTCGSSLTSGSGCGSTQTISDGYVNEAICEPDKYVASKF--GDSCRQSLSALESATQRLQVE 240
            .:               |.|:.:.||  :|...|...|:..:  |.|...:..:.:||..|....
  Rat  1536 TL---------------SRQSSASGY--QAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSP 1583

  Fly   241 LPAASKK--------------YLRETCSANSSP-----------------KLFPGHSALRLDNLS 274
            .||..:|              |.......:|||                 ...|..|...:.:.|
  Rat  1584 TPALPEKRRMSVGDRAGSLPNYATINGKVSSSPVANGMASPSGSSTVSFSHTLPDFSKYSMPDNS 1648

  Fly   275 LAEQQELK-----GAAWFQAGIPREISLEALSRQSPGAFLVRQSSTKPGCFALSLRVPPPSPR-- 332
            ...:.::|     ...|::..|.||.::..|..|.||||::|.|.:..|.:.|:::|..|.|.
  Rat  1649 PETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIT 1713

  Fly   333 ------------VAHYLILRTQRGYKIKGFTKE--FSSLKALITHHSVMPELLPVPLTLP-RPPS 382
                        |.|:||....||.|:||...|  |.||.||:..|||:|..||..|.:| |.|:
  Rat  1714 QQGKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQHSVIPLALPCKLVIPSRDPT 1778

  Fly   383 TRSQRSQGAYAGGTGNGGADFEMYGSLNDFRKMMADLNV 421
            ..|:.|.|.              ..|..|..|..|..||
  Rat  1779 DESKDSSGP--------------ANSTTDLLKQGAACNV 1803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33993	NP_001033991.1	SH2	286..364	CDD:198173	32/93 (34%)
Tns1	XP_038939258.1	C1_TNS1_v	57..112	CDD:410438
		PTP_DSP_cys	187..345	CDD:421693
		PTEN_C2	352..478	CDD:402161
		PHA03247	<718..1143	CDD:223021
		PHA03247	<1091..1643	CDD:223021	69/318 (22%)
		SH2_Tensin_like	1661..1776	CDD:198181	40/114 (35%)
		PTB_tensin	1798..1931	CDD:269924	3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45734
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010