DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33993 and TNS2

DIOPT Version :9

Sequence 1:	NP_001033991.1	Gene:	CG33993 / 3885637	FlyBaseID:	FBgn0053993	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_006719365.1	Gene:	TNS2 / 23371	HGNCID:	19737	Length:	1428	Species:	Homo sapiens

Alignment Length:	431	Identity:	95/431 - (22%)
Similarity:	143/431 - (33%)	Gaps:	159/431 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PQHSKATFISSSSA---SSSSSQTAETTLIETAEK-SPASEAAAGTV--------------TTTS 58
            |.|:.:......|.   .:.|..:|.|..:...|. .|.|:|..|..              :..|
Human   930 PLHTSSPVQGKESTRRQDTRSPTSAPTQRLSPGEALPPVSQAGTGKAPELPSGSGPEPLAPSPVS 994

  Fly    59 PQHFFHHHHPPAHPHPPRQQPHPHSHSH--------PHPHPQLQRRPVEQLHLLHSHHDVQELSG 115
            |.      .||:.|....|:..|..||.        |...|.|:..|.:               |
Human   995 PT------FPPSSPSDWPQERSPGGHSDGASPRSPVPTTLPGLRHAPWQ---------------G 1038

  Fly   116 QEHPHPQPGSHP-------HPHHLRSPSSEEDNSPT---------EMNNCRRLVDKPPL-VKRLT 163
            ...|...|...|       .|..:.||...: :|||         :.|.    :.:||| .||..
Human  1039 PRGPPDSPDGSPLTPVPSQMPWLVASPEPPQ-SSPTPAFPLAASYDTNG----LSQPPLPEKRHL 1098

  Fly   164 MGIGLLRG-------TEDSRPLMHSTCGSSLTSGSGCGSTQTISDGYVNEAICEPDKYVASKFGD 221
            .|.|...|       :..:|.:.|....:.|.|                               |
Human  1099 PGPGQQPGPWGPEQASSPARGISHHVTFAPLLS-------------------------------D 1132

  Fly   222 SCRQSLSALESATQRLQVELPAASKKYLRETCSANSSPKLFPGHSALRLDNLSLAEQQELKGAAW 286
            :..|:   .|..||..|     ::.|::::|                              ...|
Human  1133 NVPQT---PEPPTQESQ-----SNVKFVQDT------------------------------SKFW 1159

  Fly   287 FQAGIPREISLEALSRQSPGAFLVRQSSTKPGCFALSLRV--PPPSPR----------VAHYLIL 339
            ::..:.|:.::..|..:.|||||:|.|.:..|.:.|:|:|  ||||.:          |.|:||.
Human  1160 YKPHLSRDQAIALLKDKDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPVEQLVRHFLIE 1224

  Fly   340 RTQRGYKIKGFTKE--FSSLKALITHHSVMPELLPVPLTLP 378
            ...:|.||||...|  |.||.||::.||:.|..||..|.:|
Human  1225 TGPKGVKIKGCPSEPYFGSLSALVSQHSISPISLPCCLRIP 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33993	NP_001033991.1	SH2	286..364	CDD:198173	33/91 (36%)
TNS2	XP_006719365.1	C1	42..89	CDD:237996
		PTPc_motif	199..319	CDD:214649
		PTEN_C2	307..434	CDD:287393
		SH2_Tensin_like	1155..1268	CDD:198181	41/141 (29%)
		PTB_tensin	1292..1424	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157101
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45734
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940