Protein Alignment Egfrap and FER

DIOPT Version :10

• Sequence 1: NP_001033991.1
• Gene: Egfrap / 3885637
• FlyBaseID: FBgn0053993
• Length: 421
• Species: Drosophila melanogaster
• Sequence 2: XP_011541571.1
• Gene: FER / 2241
• HGNCID: 3655
• Length: 837
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 110/492 - (22%)
• Similarity: 177/492 - (35%)
• Gaps: 126/492 - (25%)

  Fly     9 RLEPQHSKATFISSSSASSSSSQTAETTLIETAEKSPASEAAAGTVTTTSPQHFFHHHHPPAHPH 73
            :.|.:..|.::.......:|:.:..:..|.:..|...|.|...   ..|...|..|:.:..|...
Human   130 KTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYD---KATMKLHMLHNQYVLALKG 191

  Fly    74 PPRQQPHPHSHSHPHPHPQLQRRPVEQLHLLHSHHD----VQELSGQE----HPHPQPGSHPHPH 130
            ....|...:..:.|.....||:...|.:..|....|    :..|..:|    |...|
Human   192 AQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQ-------- 248

  Fly   131 HLRSPSSEEDNSPTEMNNCRRLVDKPPLVKRLT--------MGIGLLRGTEDSRPLMHSTCGSSL 187
                .|.|:.:..||.||   .:|    |.|.|        ....||...|:.:  .:....::|
Human   249 ----MSVEQIDPSTEYNN---FID----VHRTTAAKEQEIEFDTSLLEENENLQ--ANEIMWNNL 300

  Fly   188 TSGSGCGSTQTISDGYV---------NEAICEPDKYVASKFGDSC------------RQSLSALE 231
            |:.|.....:|:::..:         .||:.|.:|.: .:..::|            :|:|..|:
Human   301 TAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRI-EESSETCEKKSDIVLLLSQKQALEELK 364

  Fly   232 SATQRL---------QVEL------------PAASKKYLRETCSANS------------------ 257
            .:.|:|         |.||            |.....|..:..|..|
Human   365 QSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIA 429

  Fly   258 ----SPKLFPGHSALRLDNLSLAEQQELKGAAWFQAGIPREISLEALSRQSPGAFLVRQSSTKPG 318
                |||...|.|||. |.:|::| :.|....|:...|||..:.|.|.:|  |.||||:|..|||
Human   430 GIIRSPKSALGSSALS-DMISISE-KPLAEQDWYHGAIPRIEAQELLKKQ--GDFLVRESHGKPG 490

  Fly   319 CFALSLRVPPPSPRVAHYLILRTQRGYKIKGFTKEFSSLKALITHHSVMPELLP----VPLTLPR 379
            .:.||:.   ...:..|::|......|:.:|  ..||::..||.||....:::.    |.|..|.
Human   491 EYVLSVY---SDGQRRHFIIQYVDNMYRFEG--TGFSNIPQLIDHHYTTKQVITKKSGVVLLNPI 550

  Fly   380 PPSTRSQRS-QGAYAG---GTGNGGADFEMY-GSLND 411
            |...:...| :....|   |.||.|   |:| |:|.|
Human   551 PKDKKWILSHEDVILGELLGKGNFG---EVYKGTLKD 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfrap	NP_001033991.1	SH2	286..364	CDD:198173	26/77 (34%)
FER	XP_011541571.1	F-BAR_Fer	5..238	CDD:153370	19/110 (17%)
		SMC_prok_B	107..>393	CDD:274008	52/287 (18%)
		SH2_Fps_family	453..538	CDD:198224	29/91 (32%)
		Protein Kinases, catalytic domain	566..831	CDD:473864	10/22 (45%)