DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33993 and Tns1

DIOPT Version :9

Sequence 1:	NP_001033991.1	Gene:	CG33993 / 3885637	FlyBaseID:	FBgn0053993	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_006495930.2	Gene:	Tns1 / 21961	MGIID:	104552	Length:	1922	Species:	Mus musculus

Alignment Length:	492	Identity:	122/492 - (24%)
Similarity:	166/492 - (33%)	Gaps:	120/492 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PQHSKATFISSSSASSSSSQTAETTLIETAEKSP-ASEAAAGTVTTTSPQHFFHHHHP----PAH 71
            |.:|...|  |||..|..........:.....|| |.....||.|..||.......:|    |..
Mouse  1335 PDYSLQPF--SSSPESQGQPQYSAASVHMVPGSPQARHRTVGTNTPPSPGFGRRAVNPTMAAPGS 1397

  Fly    72 PHPPRQQ---------------PHPHSHSHPHPHPQLQRRPVEQLHLLHSHHDVQELSGQEHPHP 121
            |....:|               .||.|.:.....|.|.|.||....:...|..|....|.    |
Mouse  1398 PSLSHRQVMGPSGPGFHGNVVSGHPASAATTPGSPSLGRHPVGSHQVPGLHSSVVTTPGS----P 1458

  Fly   122 QPGSHPHPHHLRSPSSEEDN------SPT---EMNNCRRLVDKPPLVKRLTMGIGLLRGTEDSRP 177
            ..|.||..|.....||...|      ||:   .:.....:|...|.:.| ....|.....||.||
Mouse  1459 SLGRHPGAHQGNLASSLHSNAVISPGSPSLGRHLGGSGSVVPGSPSLDR-HAAYGGYSTPEDRRP 1522

  Fly   178 LMHSTCGSSLTSGSGCGSTQTISDGYVNEAICEPDKYVASKF--GDSCRQSLSALESATQRLQVE 240
            .:               |.|:.:.||  :|...|...|:..:  |.|...:..:.:||..|....
Mouse  1523 TL---------------SRQSSASGY--QAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSP 1570

  Fly   241 LPAASKK--------------YLRETCSANSSP---------------KLFPGHSALRLDNLSLA 276
            .||..:|              |.......:|||               ...|..|...:.:.|..
Mouse  1571 TPALPEKRRMSVGDRAGSLPNYATINGKVSSSPVANGMASGSSTVSFSHTLPDFSKYSMPDNSPE 1635

  Fly   277 EQQELK-----GAAWFQAGIPREISLEALSRQSPGAFLVRQSSTKPGCFALSLRVPPPSPR---- 332
            .:.::|     ...|::..|.||.::..|..|.||||::|.|.:..|.:.|:::|..|.|.
Mouse  1636 TRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTITQQ 1700

  Fly   333 ----------VAHYLILRTQRGYKIKGFTKE--FSSLKALITHHSVMPELLPVPLTLP-RPPSTR 384
                      |.|:||....||.|:||...|  |.||.||:..|||:|..||..|.:| |.|:..
Mouse  1701 GKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQHSVIPLALPCKLVIPSRDPTDE 1765

  Fly   385 SQRSQGAYAGGTGNGGADFEMYGSLNDFRKMMADLNV 421
            |:.|.|.              ..|..|..|..|..||
Mouse  1766 SKDSSGP--------------ANSTTDLLKQGAACNV 1788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33993	NP_001033991.1	SH2	286..364	CDD:198173	32/93 (34%)
Tns1	XP_006495930.2	C1	<79..112	CDD:381770
		PTP_DSP_cys	189..347	CDD:391942
		PTEN_C2	354..480	CDD:371036
		PHA03247	<737..1233	CDD:223021
		PHA03247	<1073..1649	CDD:223021	71/337 (21%)
		SH2_Tensin_like	1646..1761	CDD:198181	40/114 (35%)
		PTB_tensin	1783..1916	CDD:269924	3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45734
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010