Protein Alignment Egfrap and shc-2

DIOPT Version :10

• Sequence 1: NP_001033991.1
• Gene: Egfrap / 3885637
• FlyBaseID: FBgn0053993
• Length: 421
• Species: Drosophila melanogaster
• Sequence 2: NP_494915.2
• Gene: shc-2 / 173860
• WormBaseID: WBGene00020867
• Length: 638
• Species: Caenorhabditis elegans
• Alignment Length: 355
• Identity: 81/355 - (22%)
• Similarity: 140/355 - (39%)
• Gaps: 81/355 - (22%)

  Fly    90 HPQLQRRPVEQLHLLHSHHDVQELSGQEHPHPQPGSHPHPHHLRSPSSEEDNSPT---------- 144
            |.|..:...|..::|.:.:..|.|:.::.......|..||.:..|..:|:.::.|
 Worm   249 HCQSLKEAEEIENVLRNANQSQVLAAKQPKSAVSTSSMHPTNTASTMTEKRSASTVFLNRFLGKK 313

  Fly   145 ------EMNNCRRLVDKPPLVKRLTMGIGLLRGTEDS-RPLMHSTCGS---------SLTSGSGC 193
                  |...|:|  .:.|:....:..|..|..:..| .|...||...         .|.:...|
 Worm   314 GSQTVDESGQCKR--KRRPVSAVFSSAIHRLSSSTSSVNPKRMSTIEPQAPTREQLLQLQNQMRC 376

  Fly   194 GSTQTISDGYVNEAICEPDKYVASKFGDSCRQSLSALESATQRLQVELPAASKKYLRETCSANSS 258
            .::..:.:        ||      :..|.|..|.:...|:.        |:|......:.|.::|
 Worm   377 AASSPVPE--------EP------RPTDLCAASTTTSTSSV--------ASSSSSNGSSSSTDTS 419

  Fly   259 PKLFPGHSALRLDN--------LSLAEQQELKGAAWFQAGIPREISLEALSRQSPGAFLVRQSST 315
            |......:||..|.        :..|...:|...::|.....::..:..|:.|..|||::|.|.:
 Worm   420 PVPPAPQTALVYDEKLGEWIYPIDQALMTQLDNCSYFVGQPTKDSMVYNLNTQPEGAFVIRYSES 484

  Fly   316 KPGCFALSLRVP---PPSPRVAHYLILRTQRGYKIK--GFTKEFSSLKALITHHSVMPELLPVPL 375
            |..|.|||:|||   .|| .::||||:|.::|:::|  ...|.|.:|:.::|||||:...||..|
 Worm   485 KSKCLALSMRVPCSHNPS-GISHYLIIRNEQGFRLKLSATKKPFPTLQMMLTHHSVLESHLPCTL 548

  Fly   376 -----------------TLPRPPSTRSQRS 388
                             |:.||..|.::.|
 Worm   549 HFVQWQKTNFKQLAAMSTVERPLRTFNRHS 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfrap	NP_001033991.1	SH2	286..364	CDD:198173	29/82 (35%)
shc-2	NP_494915.2	PH-like	152..268	CDD:473070	4/18 (22%)
		SH2	454..537	CDD:198173	29/83 (35%)