DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfrap and Fer

DIOPT Version :10

Sequence 1:NP_001033991.1 Gene:Egfrap / 3885637 FlyBaseID:FBgn0053993 Length:421 Species:Drosophila melanogaster
Sequence 2:NP_001033086.2 Gene:Fer / 14158 MGIID:105917 Length:823 Species:Mus musculus


Alignment Length:497 Identity:109/497 - (21%)
Similarity:171/497 - (34%) Gaps:119/497 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 IRLRLEPQHSKATFISSSSASSSSSQ------TAETTLIETAEKSPASEAAAGTV-TTTSPQHFF 63
            |..::|.:..|.|........||..|      :|:....|...|...:|.|.... ..|...|..
Mouse   117 IHQQIEAEMIKVTKTELEKLKSSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHML 181

  Fly    64 HHHHPPAHPHPPRQQPHPHSHSHPHPHPQLQRRPVEQL-------------------HLLHSHHD 109
            |:.:..|.......|...:..:.|.....:|:...|.:                   .:::.|.:
Mouse   182 HNQYVLALKGAQLHQSQYYDTTLPLLLDSVQKMQEEMIKALKGIFDDYSQITSLVTEEIVNVHKE 246

  Fly   110 VQELSGQEHPHPQPGSHPHPHHLRSPSSEEDNSPTEMNNCRRLVDKPPLVKRLTMGIGLLRGTED 174
            :|....|..|..:..:....|...:...:|....|.:     |.:...|.....|...|   |.|
Mouse   247 IQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSL-----LEENENLQANEIMWNNL---TAD 303

  Fly   175 SRPLMHSTCGSSLTSGSGCGSTQTISDGYVNEAICEPDKYVASKFGDSC------------RQSL 227
            |..:|..|....||      .||.:. .:...|:.|.:|.:...| ::|            :|:|
Mouse   304 SLQVMLKTLAEELT------QTQQML-LHKEAAVLELEKRIEESF-ETCEKKSDIVLLLGQKQAL 360

  Fly   228 SALESATQRLQ-VELPAASKK--------------------YLRETCSANS-------------- 257
            ..|:.:.|:|: .|...|::|                    |..:..|..|              
Mouse   361 EELKQSVQQLRCTEAKCAAQKALLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIR 425

  Fly   258 --------SPKLFPGHSALRLDNLSLAEQQELKGAAWFQAGIPREISLEALSRQSPGAFLVRQSS 314
                    |||...|.|....|.:|:.| :.|....|:...|||..:.|.|.:|  |.||||:|.
Mouse   426 HSIAGIIKSPKSVLGSSTQVCDVISVGE-RPLAEHDWYHGAIPRIEAQELLKQQ--GDFLVRESH 487

  Fly   315 TKPGCFALSLRVPPPSPRVAHYLILRTQRGYKIKGFTKEFSSLKALITHH----SVMPELLPVPL 375
            .|||.:.||:.   ...:..|::|......|:.:|  ..||::..||.||    .|:.:...|.|
Mouse   488 GKPGEYVLSVY---SDGQRRHFIIQFVDNLYRFEG--TGFSNIPQLIDHHFNTKQVITKKSGVVL 547

  Fly   376 TLPRPPSTR-----SQRSQGAYAGGTGNGGADFEMY-GSLND 411
            ..|.|...:     ...|.|... |.||.|   |:| |:|.|
Mouse   548 LNPIPKDKKWVLNHEDVSLGELL-GKGNFG---EVYKGTLKD 585

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrapNP_001033991.1 SH2 286..364 CDD:198173 26/77 (34%)
FerNP_001033086.2 Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250 1..300 30/187 (16%)
F-BAR_Fer 5..238 CDD:153370 20/120 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..408 1/18 (6%)
SH2_Fps_family 454..539 CDD:198224 29/91 (32%)
Protein Kinases, catalytic domain 567..817 CDD:473864 10/23 (43%)

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