DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk10 and Asic4

DIOPT Version :9

Sequence 1:	NP_001033894.1	Gene:	ppk10 / 3885617	FlyBaseID:	FBgn0065110	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_071570.2	Gene:	Asic4 / 63882	RGDID:	621068	Length:	539	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	91/508 - (17%)
Similarity:	161/508 - (31%)	Gaps:	164/508 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 HGFRYLTDSMLILFEKFLWLILLIASIYFCIIVCLSSIDRYYTKSTHIGIERNYIFWNTTLPSVT 93
            ||.|           :.||::.|:.|:...:....|....|.|:...:.::..........|:||
  Rat    63 HGLR-----------RTLWVLALLTSLAAFLYQAASLARGYLTRPHLVAMDPAAPAPVAGFPAVT 116

  Fly    94 VCPVDRL--------------NITYF----ADYCRNNGIKGPQRDILWDFLENLANSTYINFQNI 140
            :|.::|.              |:|..    .|..|..|::.|:.|::     ::.|.|
  Rat   117 LCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMV-----DILNRT------- 169

  Fly   141 PQNEQIDQIIEDIGLKPEHYTELIYNLTYDRTYEPNFNERIRCMDGAMFIHVRQVLTEWGLCYLG 205
              ..|:..:::.......|.:...:::.|                           |.:|.||..
  Rat   170 --GHQLADMLKSCNFSGHHCSASNFSVVY---------------------------TRYGKCYTF 205

  Fly   206 NSKLTEEYSSRYFIFGK----------------YPEYNKYEYE-NIRLPYQVGSFFQKDTQYA-L 252
            |:.......||....|.                :.|.|:..:| .||:  |:.|  |::..|. .
  Rat   206 NADPQSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRV--QIHS--QEEPPYIHQ 266

  Fly   253 LGF-KGPAIIAFAHSAFEVMKVDSNSDYAYDGILYDLSTEEITAEDNLEQDTTVAMR---RCRFP 313
            ||| ..|....|....                                ||..|...:   .||..
  Rat   267 LGFGVSPGFQTFVSCQ--------------------------------EQRLTYLPQPWGNCRAE 299

  Fly   314 ---HESNLTHFPFYTRNICQQECRINLAYKICKC-IPHFYPNRIANPKPVCDYKTLRSCFPHHAS 374
               .|..|..:..|:.:.|:..|......:.|.| :.|...|     :.:|.......|..|
  Rat   300 SKLREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGN-----ETICPPNIYIECADH--- 356

  Fly   375 FFLKLYEENGKHENPAICYCEQNC----HDSVVTMKSMNPMSGAKQLLGG-------------IG 422
               .|....|..|.|  |:|...|    :...::|..: |..|:.:.|..             :.
  Rat   357 ---TLDSLGGGSEGP--CFCPTPCNLTRYGKEISMVKI-PNRGSARYLARKYNRNETYIRENFLV 415

  Fly   423 SAVSVKTWPQSRLRRQVIFSLTDLLVSIGGTAGLFLGFSVLGFVEVI-YFFTI 474
            ..|..:......:.::..:.|:.||..:||..|||:|.|:|..:|:: |.:.:
  Rat   416 LDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEV 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk10	NP_001033894.1	ASC	22..471	CDD:279230	90/503 (18%)
Asic4	NP_071570.2	ASC	40..488	CDD:295594	91/508 (18%)
Asic4	NP_071570.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920