DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk10 and Asic5

DIOPT Version :9

Sequence 1:	NP_001033894.1	Gene:	ppk10 / 3885617	FlyBaseID:	FBgn0065110	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_071563.1	Gene:	Asic5 / 63866	RGDID:	69295	Length:	495	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	92/484 - (19%)
Similarity:	166/484 - (34%)	Gaps:	130/484 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KFLWLILLIASIYFCIIVCLSSIDRYYTKSTHIGIERNYIFWNTTLPSVTVC--------PVDRL 100
            |.:||.:::.|:...:....|.:..|:...|...||..|: .....|:||.|        .|.|.
  Rat    62 KVIWLSVVLGSVSLLVWQIYSRLVNYFMWPTTTSIEVQYV-EKIEFPAVTFCNLNRFQTEAVSRF 125

  Fly   101 NITYFADYCRNNGIKGPQRDILWDFL-----------ENLANSTYINFQNIPQNEQIDQIIEDIG 154
            .|.:|                |||.:           .|..:...::|....:|..|.:.:::.|
  Rat   126 GIIFF----------------LWDIVSKVLRLQEISGNNTGSPEALDFVASHRNFSITEFVKNNG 174

  Fly   155 LKPEHYTELIYNLTYDRTYEPNFNERIRCMDGAMFIHVRQVLTEWGLCYLGNSKLTEEYSSRYFI 219
            ....|.| |::...:.:|.:|.              ..:.|.||:|.|:..|.....:..::..:
  Rat   175 FYLNHDT-LVHCEFFGKTCDPK--------------DFKHVFTEYGNCFTFNYGENVQSKNKVSV 224

  Fly   220 FGKYPEYNKYEYENIRLPYQVGSFFQKDTQYALLGFKGPAIIAFAHSAFEVMKVDSNSDYAYDGI 284
            .|:          .::|...|..  ::.|...:.||....:|...||        ...:..:||:
  Rat   225 SGR----------GLKLLLDVHQ--EEFTDNPVPGFADAGVIFVIHS--------PKKEPQFDGL 269

  Fly   285 LYDLSTEEITAEDNLEQDTTVAMRRCRFPHES----------NLTHFPFYTRNICQQECRINLAY 339
              .||:.       :.....|.:|:.:..|:.          .|.:|..|:...|.:||:.....
  Rat   270 --GLSSP-------VGMHARVTIRQLKTIHQEYPWGECNPDIKLRNFTTYSTYGCLKECKAKHIQ 325

  Fly   340 KICKCIPHFYPNRIANPKPVCDYKTLRSCFPHHASFFLKLYEEN-----GKHENPAICYCEQNCH 399
            ::|.|:|...|.....    ||.....:|    .|..|...|..     |.|.:.....||:..:
  Rat   326 RLCGCLPFLLPGNGVE----CDLLKYYNC----VSPILDHIERKGLCTMGTHNSSCPVPCEETEY 382

  Fly   400 DSVVTMKSMNPMSGAKQLLGGIGSAVSVKTWPQSRLRRQVI-------------------FSLTD 445
            .:.:...:.......|.|...:..:       |..:|..::                   .|:.:
  Rat   383 PATIAYSTFPSQRATKFLAKKLNQS-------QEYIRENLVNIEINYSDLNYKITQQQKAVSVPE 440

  Fly   446 LLVSIGGTAGLFLGFSVLGFVEVI-YFFT 473
            ||..:||..|||.|.|::..:|:| |.||
  Rat   441 LLADVGGQLGLFCGASLITIIEIIEYLFT 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk10	NP_001033894.1	ASC	22..471	CDD:279230	89/480 (19%)
Asic5	NP_071563.1	deg-1	40..465	CDD:273309	88/478 (18%)
Asic5	NP_071563.1	ASC	41..466	CDD:279230	89/479 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820