DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk10 and ASIC5

DIOPT Version :9

Sequence 1:	NP_001033894.1	Gene:	ppk10 / 3885617	FlyBaseID:	FBgn0065110	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_059115.1	Gene:	ASIC5 / 51802	HGNCID:	17537	Length:	505	Species:	Homo sapiens

Alignment Length:	486	Identity:	115/486 - (23%)
Similarity:	177/486 - (36%)	Gaps:	105/486 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 HGFRYLTDSMLILFEKFLWLILLIASIYFCIIVCLSSIDRYYTKSTHIGIERNYIFWNTTLPSVT 93
            ||...:..:...: .:.|||::::.|:..........:..|:|..|...||..|: .....|:||
Human    48 HGIHNIVQNRSKI-RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYV-EKMEFPAVT 110

  Fly    94 VCPVDRLNITYFADYCRNNGIKGPQRDILWDFL-------ENLANST----YINFQNIPQNEQID 147
            .|.::|......|.:    |:    ...||..:       |..||||    ..:|....||..|.
Human   111 FCNLNRFQTDAVAKF----GV----IFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIV 167

  Fly   148 QIIEDIGLKPEHYTELIYNLTYDRTYEPNFNERIRCMDGAMFIHVRQVLTEWGLCYLGNSKLTEE 212
            :.|.:.|....:.|.|      |..:   |.:.....|   |.|   |.||:|.|:..|...|.:
Human   168 EFIRNKGFYLNNSTLL------DCEF---FGKPCSPKD---FAH---VFTEYGNCFTFNHGETLQ 217

  Fly   213 YSSRYFIFGKYPEYNKYEYENIRLPYQVGSFFQKDTQYALLGFKGPAIIAFAHSAFEVMKVDSNS 277
            ...:..:.|:          .:.|.:.|..  :..|....|||....||...||..:|.:
Human   218 AKRKVSVSGR----------GLSLLFNVNQ--EAFTDNPALGFVDAGIIFVIHSPKKVPQ----- 265

  Fly   278 DYAYDGILYDLSTEEITAEDNLEQDTTVAMRRCRFP-HESN----LTHFPFYTRNICQQECRINL 337
               :|| |..||...:.|...:.|..||..   .:| .|.|    |.:|..|:.:.|.:||:...
Human   266 ---FDG-LGLLSPVGMHARVTIRQVKTVHQ---EYPWGECNPNIKLQNFSSYSTSGCLKECKAQH 323

  Fly   338 AYKICKCIPHFYPNRIANPKPVCDYKTLRSCFP---HHASFFLKLYEENGKHENPAICYCEQNCH 399
            ..|.|.|:|...|.....    ||.:...||..   .|..|  |.....|.|.:.....||:..:
Human   324 IKKQCGCVPFLLPGYGIE----CDLQKYFSCVSPVLDHIEF--KDLCTVGTHNSSCPVSCEEIEY 382

  Fly   400 DSVVTMKSMNPMSGAKQLLGGIGSAVSVKTWPQSR---------------------LRRQVIFSL 443
            .:.::..|.......|.|         .|...|||                     .::|...|:
Human   383 PATISYSSFPSQKALKYL---------SKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSV 438

  Fly   444 TDLLVSIGGTAGLFLGFSVLGFVEVI-YFFT 473
            ::||..:||..|||.|.|::..:|:| |.||
Human   439 SELLADLGGQLGLFCGASLITIIEIIEYLFT 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk10	NP_001033894.1	ASC	22..471	CDD:279230	112/482 (23%)
ASIC5	NP_059115.1	ASC	41..466	CDD:279230	112/481 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820