DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk10 and asic1b

DIOPT Version :9

Sequence 1:	NP_001033894.1	Gene:	ppk10 / 3885617	FlyBaseID:	FBgn0065110	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_999956.1	Gene:	asic1b / 407672	ZFINID:	ZDB-GENE-040513-1	Length:	557	Species:	Danio rerio

Alignment Length:	526	Identity:	113/526 - (21%)
Similarity:	185/526 - (35%)	Gaps:	163/526 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YFNNCCIHGFRYLTDSMLILFEKF-----LW-LILLIASIYFCIIVCLSSIDR--YYTKSTHIGI 78
            :|..|.:||    .:.:.:..:||     || |:.|:|...|.:.|    :||  ||.:..::.:
Zfish    69 FFGGCSLHG----ANHVFVEDKKFSIRQGLWALVFLLAISMFLLQV----VDRVIYYLQYDYVTL 125

  Fly    79 --ERNYIFWNTTLPSVTVCPVD---RLNITYFADYCRNNGIKGPQRDILWDFLENLANSTYINFQ 138
              |||  ..|.|.|::|:|..:   |..::| :|..    ..||    |..:.:|:|       .
Zfish   126 LDERN--AKNMTFPAITLCNYNTFRRSQLSY-SDLL----FMGP----LLGYEDNMA-------P 172

  Fly   139 NIPQNEQIDQIIEDIGLKPEHYTELIYNLTYDRTYEPNFNERIRCMDGAMFIHVRQVLTEWGLCY 203
            .||...:.|:......| .|.:....:.:. |...|.||..: .|  ||.  |.|::.|.:|.||
Zfish   173 GIPLAPEPDRQGSRFSL-AEFFNRTRHRMD-DMLLECNFAGK-EC--GAE--HWREIFTRYGKCY 230

  Fly   204 LGNSKLTEEYSSRYFIFGKYPEYNKYEYENIRLPYQVGSFFQKDTQYALLGFKGPAIIAFAHSAF 268
            ..||                                     .:|.:..|:..||.     ..:..
Zfish   231 TFNS-------------------------------------GQDGRPLLITTKGG-----MGNGL 253

  Fly   269 EVMKVDSNSDYAYDGILYDLSTEEITAEDNLE-----QDTTVAMRRCRFP-----------HESN 317
            |:| :|...| .|..:..:  |:|.|.|..::     ||....:.:..|.           .|..
Zfish   254 EIM-LDIQQD-EYLPVWGE--TDETTFEAGIKVQIHTQDEPPFIDQLGFGVAPGFQTFVSCQEQR 314

  Fly   318 LTHFP---------------FYTRNI--CQQECRINLAYKICKCIPHFYPNRIANPKPVCDYKTL 365
            ||:.|               |.|.:|  |:.:|......:.|.|.....|    ...|.|..:..
Zfish   315 LTYLPPPWGDCKATPIDSDFFNTYSITACRIDCETRYLVENCNCRMVHMP----GDAPYCTPEQY 375

  Fly   366 RSCFPHHASFFLKLYEENGKHENPAICYCEQNC----HDSVVTMKSMNPMSGAKQL--------- 417
            :.|......|   |.|.:..:     |.||..|    :...::...:...:.||.|
Zfish   376 KECADPALDF---LVERDNDY-----CVCETPCNMTRYGKELSFVRIPSKASAKYLAKKYNKTEQ 432

  Fly   418 --------LGGIGSAVSVKTWPQSRLRRQVIFSLTDLLVSIGGTAGLFLGFSVLGFVEVIYFFTI 474
                    |.....|::.:|..|.:     .:.|..||..|||..|||:|.|:|..:|:..:...
Zfish   433 YISDNIMVLDIFFEALNYETIEQKK-----AYELAGLLGDIGGQMGLFIGASILTILELFDYLYE 492

  Fly   475 RIVFQI 480
            .|.|::
Zfish   493 VIKFKL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk10	NP_001033894.1	ASC	22..471	CDD:279230	111/515 (22%)
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..57
		ASC	66..548	CDD:295594	113/526 (21%)
		Selectivity filter. /evidence=ECO:0000305	477..479		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020