DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk10 and ASIC2

DIOPT Version :9

Sequence 1:	NP_001033894.1	Gene:	ppk10 / 3885617	FlyBaseID:	FBgn0065110	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_899233.1	Gene:	ASIC2 / 40	HGNCID:	99	Length:	563	Species:	Homo sapiens

Alignment Length:	541	Identity:	112/541 - (20%)
Similarity:	175/541 - (32%)	Gaps:	174/541 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IHGFRYLTDSMLILFEKF----LWLILLIASIYFCIIVCLSSIDRYYTKS--THIGIERNYIFWN 86
            :||.|::..........|    ||::....|  |.:::..||....|..|  :|..:.|.   |:
Human    66 LHGLRHMCAGRTAAGGSFQRRALWVLAFCTS--FGLLLSWSSNRLLYWLSFPSHTRVHRE---WS 125

  Fly    87 TTL--PSVTVCPVDRLNI-------TYFADYCRNNGIKGPQR-------DIL--------WDFLE 127
            ..|  |:||||..:.|..       .|:|.:..  |:..|.|       ::|        |  ..
Human   126 RQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWL--GLLLPNRTARPLVSELLRGDEPRRQW--FR 186

  Fly   128 NLANSTYI----NFQNIPQ--NEQIDQIIEDIGLKPEHYTELIYNLTYDRTYEP-NFNERIRCMD 185
            .||:....    :|:.|..  .:::...:||:.|..::..||.         .| ||:
Human   187 KLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELC---------GPHNFS------- 235

  Fly   186 GAMFIHVRQVLTEWGLCYLGNS------KLT------------------EEYSSRYFIFGKYPEY 226
                    .|.|::|.||:.||      .||                  :||         .|.:
Human   236 --------SVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEY---------LPIW 283

  Fly   227 NKYEYENIRLPYQVGSFFQKDTQYAL-LGFKGPAIIAFAHSAFEVMKVDSNSDYAYDGILYDLST 290
            .:.|........:|....|.:..:.. |||                           |:.....|
Human   284 GETEETTFEAGVKVQIHSQSEPPFIQELGF---------------------------GVAPGFQT 321

  Fly   291 EEITAEDNLEQDTTVAMRRCRFPHESNLTHFPFYTRNICQQECRINLAYKICKCIPHFYPNRIAN 355
            ...|.|..|.. .......|| ..|..|..||.|:...|:.:|......:.|.|.....|    .
Human   322 FVATQEQRLTY-LPPPWGECR-SSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMP----G 380

  Fly   356 PKPVCDYKTLRSCFPHHASFFLKLYEENGKHENPAICYCEQNC----HDSVVTMKSMNPMSGAKQ 416
            ..|.|..:..:.|    |...|.|..|  |..|  .|.|...|    ::..::|..:...:.||.
Human   381 DAPFCTPEQHKEC----AEPALGLLAE--KDSN--YCLCRTPCNLTRYNKELSMVKIPSKTSAKY 437

  Fly   417 L-----------------LGGIGSAVSVKTWPQSRLRRQVIFSLTDLLVSIGGTAGLFLGFSVLG 464
            |                 |.....|::.:|..|.:     .:.:..||..|||..|||:|.|:|.
Human   438 LEKKFNKSEKYISENILVLDIFFEALNYETIEQKK-----AYEVAALLGDIGGQMGLFIGASILT 497

  Fly   465 FVEV---IYFFTIRIVFQILG 482
            .:|:   ||......:..:||
Human   498 ILELFDYIYELIKEKLLDLLG 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk10	NP_001033894.1	ASC	22..471	CDD:279230	109/528 (21%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	112/541 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920