Protein Alignment ppk16 and asic1a

DIOPT Version :10

• Sequence 1: NP_001334673.1
• Gene: ppk16 / 3885612
• FlyBaseID: FBgn0065108
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_999955.1
• Gene: asic1a / 791696
• ZFINID: ZDB-GENE-040513-2
• Length: 501
• Species: Danio rerio
• Alignment Length: 509
• Identity: 120/509 - (23%)
• Similarity: 191/509 - (37%)
• Gaps: 124/509 - (24%)

  Fly    59 YCQTTSLHGFSYITRQDISRHERWFWLVVVILAIITSIVLVV---VSWYWSQETPTVTVIESSHF 120
            :..|::|||.|:|...:....:...| ||..|:.:|.::.|.   :.:|  .|.|.||.::....
Zfish    26 FAHTSTLHGISHIFSYEKITAKCCLW-VVFFLSSLTFLMYVCIDRIQFY--LEYPHVTKLDEITT 87

  Fly   121 PTWNIPFPAVTICNFNKISKSKALSLLDQMQVPVGINRSELHNLFNLTLL-----------PVDT 174
            |.  :.||||||||.|.|..|:             |.|::|::...|..|           .|:.
Zfish    88 PV--MVFPAVTICNLNSIRFSR-------------ITRNDLYHAGELLALLNSRHEVREAHLVEE 137

  Fly   175 MISNDSLQKYD-RILSLNNLTLNRLTQQLSPDCIEMISSCIWKGINTRCESLFQRIDTMEGQCCT 238
            .:......|.| |.....:..:.....:...|..:|:.||.::|...|.|. |..:.|..|:|.|
Zfish   138 SVMEVLKSKTDFRSFKPRHFNMWEFYNRTGHDIKDMLLSCQFRGSPCRPED-FSVVFTRYGKCYT 201

  Fly   239 FNYFGGISNNFPEKIAYQVPKRPYRVTGCGYPTGLSVLLNPMISDYY--------GTFFSGFGFR 295
            ||    .....|.:::         |.| |...||.::|:....:|.        .:|.:|...:
Zfish   202 FN----SGETGPPRVS---------VKG-GMGNGLEIMLDIQQDEYLPVWGESDESSFEAGIKVQ 252

  Fly   296 LLLHDAYNFPDE-------NSETKVVTTTRESFVRI-----NPESTYATNDIRRMDLSLRNCLFG 348
            :...|...|.|:       ..:| .|:...:..|.:     :.:||..::|.
Zfish   253 IHSQDEPPFIDQLGFGVAPGFQT-FVSCQEQRLVYLPAPWGSCKSTPPSSDY------------- 303

  Fly   349 SEMTMHGLRRYSFINCMFECRVRMTVDLCGCLPPYVYNNGSYKVC-GVLQTNCIIHSKRLFSHAL 412
                   .|.||...|..:|..|..|:.|.|  ..|:..|....| .||...|        :|.
Zfish   304 -------FRAYSISACRTDCETRYLVENCNC--RMVHMPGDAPYCTPVLYKEC--------AHP- 350

  Fly   413 ANLNFSLSIVRETDSFPCGCLPDCQSNHYVSE----STTGRLDISYFANRPTFNN--ATDRIL-L 470
                 :|..:.||||..|.|...|....|..|    ....:..:.|.|.:.:.:.  .|:.:: |
Zfish   351 -----ALDFLVETDSDYCSCETPCNITRYSKELSFVKIPSKASVKYLAKKYSKSEKYITENVMVL 410

  Fly   471 HVFFSDLMSTRYRTDIFQ----NWLSALASFGGLLGLIMGFSIVT---AFEFIY 517
            .|||..|   .|.| |.|    .....|...||.:||.:|.||:|   .|:::|
Zfish   411 DVFFEAL---NYET-IEQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDYLY 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk16	NP_001334673.1	ASC	59..518	CDD:459966	120/509 (24%)
asic1a	NP_999955.1	ENaC	23..469	CDD:273304	120/509 (24%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	446..448		1/1 (100%)