Protein Alignment ppk16 and SCNN1D

DIOPT Version :9

• Sequence 1: NP_001334673.1
• Gene: ppk16 / 3885612
• FlyBaseID: FBgn0065108
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 109/593 - (18%)
• Similarity: 186/593 - (31%)
• Gaps: 186/593 - (31%)

  Fly    30 PMHNHSHNPIQPQHRFRQIGEWFTENMRNYCQTTSLHGFSYITRQDISRHERWFWLVVVILAIIT 94
            |...|....::....||::..:|       |...::||   ..|...||..|   |......:::
Human   205 PKEGHQEGLVELPASFRELLTFF-------CTNATIHG---AIRLVCSRGNR---LKTTSWGLLS 256

  Fly    95 SIVLVVVSW--------YWSQETPTVTVIESSHFPTWNIPFPAVTICNFNKISKS---KALSLLD 148
            ...||.:.|        :|.:.......:.|.     ....|.||:|:.|....|   :.|.|||
Human   257 LGALVALCWQLGLLFERHWHRPVLMAVSVHSE-----RKLLPLVTLCDGNPRRPSPVLRHLELLD 316

  Fly   149 QMQVPVGINRSELHNLFNLTLLPVDTMIS-----NDSLQKYDRILSLNNLTLN--------RLTQ 200
            :..      |..:.:|:|:.|......:|     ::.....||.:.|..|:.:        ||..
Human   317 EFA------RENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCN 375

  Fly   201 QLSPDCI---------------------------------------EMISSCIWKGINTRCESLF 226
            ....||.                                       ..:.||.:.|::.:.....
Human   376 STGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFR 440

  Fly   227 QRIDTMEGQCCTFNYFGGISNNFPEKIAYQVPKRPYRVTGCGYPTGLSVLLN-------PMISDY 284
            .......|.|.|.:   |:          ...:||      |...|:.::|.       |::|..
Human   441 TFHHPTYGSCYTVD---GV----------WTAQRP------GITHGVGLVLRVEQQPHLPLLSTL 486

  Fly   285 YGTFFSGFGFRLLLHDAYNFPDENSETKVVTTTRESF-VRINPESTYA--TNDIRRMDLSLRNCL 346
                   .|.|:::|...:.|         .....|| ||...|:|.:  .:::.|:.....:|.
Human   487 -------AGIRVMVHGRNHTP---------FLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCT 535

  Fly   347 FGSE-MTMHGLRRYSFIN--CMFECRVRMTVDLCGC------LPPYVYNNGSYKVCGVLQTNCII 402
            .|.| :.:..|...|:..  |:..|..::.|:.|.|      ||.    ...|         |..
Human   536 AGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPA----GAEY---------CSS 587

  Fly   403 HSKRLFSHALANLNFSLSIVRETDSFPC--GCLPDCQSNHYVSESTTGRLDISYFANRPTFNNAT 465
            .....:.|....|...|    ||...||  .|...|:.:.:...:.|.|...:..|.. |.....
Human   588 ARHPAWGHCFYRLYQDL----ETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGW-TLATLG 647

  Fly   466 DRILLHVFFSDLMSTRYRTD------IFQ--NWLSA-----------LASFGGLLGLIMGFSIVT 511
            ::.|.|      .|.|.|:.      ::|  |:.|.           |::.|.|..|..|.|:::
Human   648 EQGLPH------QSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLS 706

  Fly   512 AFEFIYFL 519
            ..|.:..|
Human   707 LLELLELL 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk16	NP_001334673.1	None
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		2/5 (40%)
		ENaC	219..784	CDD:273304	107/579 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740