Protein Alignment ppk16 and SCNN1A

DIOPT Version :10

• Sequence 1: NP_001334673.1
• Gene: ppk16 / 3885612
• FlyBaseID: FBgn0065108
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 612
• Identity: 116/612 - (18%)
• Similarity: 201/612 - (32%)
• Gaps: 213/612 - (34%)

  Fly    38 PIQPQ------------HR-FRQIGEWFTENMRNYCQTTSLHGFSYITRQDISRHERW---FWLV 86
            |..||            || :|::.|:|       |..|::||   ..|...|:|.|.   ||.|
Human    94 PAAPQQPTAEEEALIEFHRSYRELFEFF-------CNNTTIHG---AIRLVCSQHNRMKTAFWAV 148

  Fly    87 VVILAIITSIVLVVVSW-------YWS-----QETPTVTVIESSHFPTWNIPFPAVTICNFNKIS 139
            :               |       ||.     .|..:..|..:.:..:..:.|||||||..|...
Human   149 L---------------WLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYR 198

  Fly   140 KSKALSLLDQMQ-------------------VPVGINRSEL-----HNLFNLTLLP--------- 171
            ..:....|:::.                   |....:|.:|     |.|..|.:.|
Human   199 YPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRAR 263

  Fly   172 -------------------VDTMISN---------------DSLQKYDRILSLNNLTLNRLTQ-- 200
                               :...:.|               |:::::.|...:|  .|:||.:
Human   264 SVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYIN--ILSRLPETL 326

  Fly   201 -QLSPDCI-EMISSCIWKGINTRCESLFQRIDTMEGQCCTFNYFGGISNNFPEKIAYQVPKRPYR 263
             .|..|.: ..|.:|.:..::....:.......|.|.|.|||     ..|........:|
Human   327 PSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFN-----DKNNSNLWMSSMP----- 381

  Fly   264 VTGCGYPTGLSVLLNPMISDYYGTFFSGFGFRLLLH--DAYNFPDENS-------ETKVVTTTRE 319
                |...|||::|....:|:.....:..|.|:::|  |...|.|:..       ||. ::..:|
Human   382 ----GINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETS-ISMRKE 441

  Fly   320 SFVRINPESTYATNDIRRMDLSLRNCLFGSEMTMHGL--RRYSFINCMFECRVRMTVDLCGCLPP 382
            :..|:..:....|.:             ||::.:..|  .:|:...|:..|.....:..|||  .
Human   442 TLDRLGGDYGDCTKN-------------GSDVPVENLYPSKYTQQVCIHSCFQESMIKECGC--A 491

  Fly   383 YVY----NNGSYKVCGVLQTNCIIHSKRLFSHALANLNFSLSIVRETDSFPCGCLPDCQSNHYVS 443
            |::    .|..|  |...:     ||...:.:....::||        |...||...|:....|
Human   492 YIFYPRPQNVEY--CDYRK-----HSSWGYCYYKLQVDFS--------SDHLGCFTKCRKPCSV- 540

  Fly   444 ESTTGRLDISYF-----------------ANRPTFNNATDRIL-LHVFFSDLMSTRYRTDIFQ-- 488
              |:.:|...|.                 .|..|.||..:.:. :::||.:|   .|:|:...
Human   541 --TSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKEL---NYKTNSESPS 600

  Fly   489 -NWLSALASFGGLLGLIMGFSIVTAFE 514
             ..::.|::.|....|..|.|:::..|
Human   601 VTMVTLLSNLGSQWSLWFGSSVLSVVE 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk16	NP_001334673.1	ASC	59..518	CDD:459966	108/578 (19%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	111/593 (19%)