DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk16 and ASIC5

DIOPT Version :9

Sequence 1:	NP_001334673.1	Gene:	ppk16 / 3885612	FlyBaseID:	FBgn0065108	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_059115.1	Gene:	ASIC5 / 51802	HGNCID:	17537	Length:	505	Species:	Homo sapiens

Alignment Length:	505	Identity:	118/505 - (23%)
Similarity:	188/505 - (37%)	Gaps:	120/505 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 NYCQTTSLHGFSYITRQDISRHERWFWLVVVI--LAIIT-SIVLVVVSWY-WSQETPTVTVIESS 118
            ::..:||.||...|. |:.|:..|..|||||:  ::::| .|.:.::::: |    ||.|.||..
Human    40 DFAISTSFHGIHNIV-QNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTW----PTTTSIEVQ 99

  Fly   119 HFPTWNIPFPAVTICNFNK-----ISK-----------SKALSLLDQMQVPVGINR----SELHN 163
            :..  .:.|||||.||.|:     ::|           ||.|.|.:......|...    :..|.
Human   100 YVE--KMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQ 162

  Fly   164 LFNLTLLPVDTMISNDSLQKYDRILSLNNLTLNRLTQQLSPDCIEMISSCIWKGINTRCESLFQR 228
            .|::.     ..|.|....       |||.||        .||......|..|.        |..
Human   163 NFSIV-----EFIRNKGFY-------LNNSTL--------LDCEFFGKPCSPKD--------FAH 199

  Fly   229 IDTMEGQCCTFNYFGGISNNFPEKIAYQVPKRPYRVTGCGYPTGLSVLLN---PMISDYYGTFFS 290
            :.|..|.|.|||:...:.           .||...|:|    .|||:|.|   ...:|.....|.
Human   200 VFTEYGNCFTFNHGETLQ-----------AKRKVSVSG----RGLSLLFNVNQEAFTDNPALGFV 249

  Fly   291 GFGFRLLLHDAYNFPDENSETKVVTTTRESFVRINPESTYATNDIRRMDLSLRNCLFGS---EMT 352
            ..|...::|.....|.           .:....::|...:|...||::....:...:|.   .:.
Human   250 DAGIIFVIHSPKKVPQ-----------FDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPNIK 303

  Fly   353 MHGLRRYSFINCMFECRVRMTVDLCGCLPPYVYNNGSYKVCGVLQT--NCIIHSKRLFSHALANL 415
            :.....||...|:.||:.:.....|||:|   :....|.:...||.  :|:       |..|.::
Human   304 LQNFSSYSTSGCLKECKAQHIKKQCGCVP---FLLPGYGIECDLQKYFSCV-------SPVLDHI 358

  Fly   416 NF-SLSIVRETDSFPCGCLPDCQSNHYVS----ESTTGRLDISYFANRPTFNNATDR---ILLHV 472
            .| .|..|...:|   .|...|:...|.:    .|...:..:.|.:.:...:....|   :.:.:
Human   359 EFKDLCTVGTHNS---SCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI 420

  Fly   473 FFSDLMSTRYRTDIFQNWLSA---LASFGGLLGLIMGFSIVTAFEFIYFL 519
            .:|||   .|:....|..:|.   ||..||.|||..|.|::|..|.|.:|
Human   421 NYSDL---NYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYL 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk16	NP_001334673.1	None
ASIC5	NP_059115.1	ASC	41..466	CDD:279230	117/501 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710