Protein Alignment ppk16 and ASIC1

DIOPT Version :10

• Sequence 1: NP_001334673.1
• Gene: ppk16 / 3885612
• FlyBaseID: FBgn0065108
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 117/570 - (20%)
• Similarity: 192/570 - (33%)
• Gaps: 181/570 - (31%)

  Fly    55 NMRNYCQTTSLHGFSYITRQDISRHERWFWLVVVI--LAIITSIVLVVVSWYWSQETPT-VTVIE 116
            :::.:..:::|||.::|...:....:|..|.:..:  ||::..:....|.:|:.....| :..:.
Human    17 SIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVA 81

  Fly   117 SSHFPTWNIPFPAVTICN-----FNKISKS------KALSLLDQMQVPVGINRSELHNLFNLTLL 170
            :|     .:.|||||:||     |:::||:      :.|:||:        ||.|:
Human    82 AS-----QLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLN--------NRYEI--------- 124

  Fly   171 PVDTMISNDS----LQKYDRILSLNNLTLN--RLTQQLSPDCIEMISSCIWKGINTRCESLFQRI 229
             .||.::::.    ||......|......|  ....:...|..:|:.||.::|.....|. |:.:
Human   125 -PDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAED-FKVV 187

  Fly   230 DTMEGQCCTFNYFGGISNNFPEKIAYQVPKRPYRVTGCGYPTGLSVLLNPMISDY---YG----T 287
            .|..|:|.|||  .|....         |:......|.|  .||.::|:....:|   :|    |
Human   188 FTRYGKCYTFN--SGRDGR---------PRLKTMKGGTG--NGLEIMLDIQQDEYLPVWGETDET 239

  Fly   288 FFSGFGFRLLLH--------DAYNFPDENSETKVVTTTRESFVRINPESTYATNDIRRMDLSLRN 344
            .|.. |.::.:|        |...|.........|....:..:.:.|  .:.|.....||..|.
Human   240 SFEA-GIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPP--PWGTCKAVTMDSDLD- 300

  Fly   345 CLFGSEMTMHGLRRYSFINCMFECRVRMTVDLCGC----LP---PYVYNNGSYKVCGVLQTNCII 402
             .|.|         ||...|..:|..|..|:.|.|    :|   ||. ....||.|.
Human   301 -FFDS---------YSITACRIDCETRYLVENCNCRMVHMPGDAPYC-TPEQYKECA-------- 346

  Fly   403 HSKRLFSHALANLNFSLSIVRETDSFPCGCLPDCQSNHYVSE----STTGRLDISYFANRPTFNN 463
                         :.:|..:.|.|...|.|...|....|..|    ....:....|.|.:  ||.
Human   347 -------------DPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKK--FNK 396

  Fly   464 ATDRI-----LLHVFF--------------------SDLMST------------RYRTDIFQNWL 491
            :...|     :|.:||                    .:|:.|            .|......:.|
Human   397 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLL 461

  Fly   492 S--------------ALASFGGLLGLIMGFSIVTAFEFIYFLTFRPVFNY 527
            |              .|...||.:||.:|.||:|..|         :|:|
Human   462 SHEGPPPQRPFPKPCCLGDIGGQMGLFIGASILTVLE---------LFDY 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk16	NP_001334673.1	ASC	59..518	CDD:459966	115/555 (21%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	117/568 (21%)