DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk16 and asic1b

DIOPT Version :9

Sequence 1:	NP_001334673.1	Gene:	ppk16 / 3885612	FlyBaseID:	FBgn0065108	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_999956.1	Gene:	asic1b / 407672	ZFINID:	ZDB-GENE-040513-1	Length:	557	Species:	Danio rerio

Alignment Length:	503	Identity:	120/503 - (23%)
Similarity:	189/503 - (37%)	Gaps:	134/503 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SLHGFSYITRQDISRHER-WFWLVVVILAIITSIVLVVVSWYWSQETPTVTVIESSHFPTWNIPF 127
            ||||.:::..:|.....| ..|.:|.:|||...::.||....:..:...||:::..:  ..|:.|
Zfish    74 SLHGANHVFVEDKKFSIRQGLWALVFLLAISMFLLQVVDRVIYYLQYDYVTLLDERN--AKNMTF 136

  Fly   128 PAVTICNFNKISKSKALSLLDQMQVPVGINRSELHNLFNLTLLPV-DTMISNDSL-QKYDRILSL 190
            ||:|:||:|...:|:             ::.|:|  ||...||.. |.|.....| .:.||..|.
Zfish   137 PAITLCNYNTFRRSQ-------------LSYSDL--LFMGPLLGYEDNMAPGIPLAPEPDRQGSR 186

  Fly   191 NNLT--LNRLTQQLSPDCIEMISSCIWKGINTRCESLFQRIDTMEGQCCTFNYFGGISNNFPEKI 253
            .:|.  .||...::.    :|:..|.:.|.....|. ::.|.|..|:|.|||  .|...
Zfish   187 FSLAEFFNRTRHRMD----DMLLECNFAGKECGAEH-WREIFTRYGKCYTFN--SGQDG------ 238

  Fly   254 AYQVPKRPYRVT---GCGYPTGLSVLLNPMISDY---YG-----TFFSGFGFRLLLHDAYNFPDE 307
                  ||..:|   |.|  .||.::|:....:|   :|     ||.:|...::...|...|.|:
Zfish   239 ------RPLLITTKGGMG--NGLEIMLDIQQDEYLPVWGETDETTFEAGIKVQIHTQDEPPFIDQ 295

  Fly   308 -------NSETKVVTTTRESFVRINP-----ESTYATNDIRRMDLSLRNCLFGSEMTMHGLRRYS 360
                   ..:| .|:...:....:.|     ::|...:|.                    ...||
Zfish   296 LGFGVAPGFQT-FVSCQEQRLTYLPPPWGDCKATPIDSDF--------------------FNTYS 339

  Fly   361 FINCMFECRVRMTVDLCGC----LP---PYVYNNGSYKVCGVLQTNCIIHSKRLFSHALANLNFS 418
            ...|..:|..|..|:.|.|    :|   ||. ....||.|.                     :.:
Zfish   340 ITACRIDCETRYLVENCNCRMVHMPGDAPYC-TPEQYKECA---------------------DPA 382

  Fly   419 LSIVRETDSFPCGCLPDCQSNHYVSESTTGRL----DISYFANR--PTFNNATDRIL-LHVFFSD 476
            |..:.|.|:..|.|...|....|..|.:..|:    ...|.|.:  .|....:|.|: |.:||..
Zfish   383 LDFLVERDNDYCVCETPCNMTRYGKELSFVRIPSKASAKYLAKKYNKTEQYISDNIMVLDIFFEA 447

  Fly   477 LMSTRYRTDIFQNWLSALA----SFGGLLGLIMGFSIVT---AFEFIY 517
            |   .|.| |.|.....||    ..||.:||.:|.||:|   .|:::|
Zfish   448 L---NYET-IEQKKAYELAGLLGDIGGQMGLFIGASILTILELFDYLY 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk16	NP_001334673.1	None
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..57
		ASC	66..548	CDD:295594	120/503 (24%)
		Selectivity filter. /evidence=ECO:0000305	477..479		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586669
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840