DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk16 and asic4a

DIOPT Version :9

Sequence 1:	NP_001334673.1	Gene:	ppk16 / 3885612	FlyBaseID:	FBgn0065108	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_999952.1	Gene:	asic4a / 407668	ZFINID:	ZDB-GENE-040513-5	Length:	539	Species:	Danio rerio

Alignment Length:	506	Identity:	114/506 - (22%)
Similarity:	189/506 - (37%)	Gaps:	123/506 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 TENMRNYCQTTSLHGFSYI-------TRQDISRHERWFWLVVVILAIITSIVLVV-------VSW 103
            |:::..:...:||||.::|       .||.:       |    .||.:.|:.|.:       :|:
Zfish    38 TKDLAGFASASSLHGINHIFVSGRLGVRQTL-------W----ALAFLVSLALFLYQAAKCAISY 91

  Fly   104 YWSQETPTVTVIESSHFPTWNIPFPAVTICNFNKISKSKALSLLDQMQVPVGINRSELHNLFNLT 168
            .   |.|.||.:.....|  .:.||||||||.|:...|   :|.|          :::::|.|||
Zfish    92 L---EHPHVTALNEEATP--EMVFPAVTICNINRFRFS---ALTD----------ADIYHLANLT 138

  Fly   169 LLPVDTMISNDSLQKYDRILSLNNL--TLNRLTQQLSPDCIEMISSCIWKGINTRCESLFQRIDT 231
            .||..   :.|..:..|......::  ..||...||.    ||:.||.:.|.|...|. |..:.|
Zfish   139 GLPPK---NKDGHKPTDLEYPAPDMQDIFNRTGHQLE----EMLKSCNFSGQNCSAED-FTVVYT 195

  Fly   232 MEGQCCTFNYFGGISNNFPEKIAYQVPKRPYRVTGCGYPTGLSVLLNPMISDYYGTFFS------ 290
            ..|:|.|||             ..:...|..:..|.|  .||.::|:....||...:..
Zfish   196 RYGKCYTFN-------------GNKTTSRKTKQGGMG--NGLEIMLDIQQDDYLPIWKETNETSL 245

  Fly   291 GFGFRLLLHDAYNFPDENSETKVVTTTRESFVRINPES-TYATNDIRRMDLSLRNCLFGSEMTMH 354
            ..|.|:.:|.....|..:.....|:...::||....:. ||       :.....||...||..:.
Zfish   246 EAGIRVQIHSQDEPPYIHQLGFGVSPGFQTFVSCQEQRLTY-------LPQPWGNCRSTSEQMIP 303

  Fly   355 GLRRYSFINCMFECRVRMTVDLCGCLPPYVYNNGSYKVCGVLQTNCIIHSKRLFSHALANLNFSL 419
            |...||...|...|.....:..|.|  ..|:..|...:|......|:              :.:|
Zfish   304 GYDTYSISACRLRCETLEVLRECKC--RMVHMPGDANICTPSDIKCV--------------DKAL 352

  Fly   420 SIVRETDSFPCGCLPDCQSNHYVSESTTGRL----DISYFANRPTFNNATDRI-----LLHVFFS 475
            ::::::....|.|...|....|..|.:..::    ...|.:.:  ::.:.|.|     :|.:||.
Zfish   353 ALLQKSSGDTCFCETPCNLTRYGKELSMVKIPSKGSARYLSRK--YDKSEDYIRDNFLVLDIFFE 415

  Fly   476 DLMSTRYRT-------DIFQNWLSALASFGGLLGLIMGFSIVTAFEFIYFL 519
            .|   .|.|       |:    ...|...||.:||.:|.|::|..|.:.::
Zfish   416 AL---NYETIEQKKAYDV----AGLLGDIGGQMGLFIGASVLTILEILDYV 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk16	NP_001334673.1	None
asic4a	NP_999952.1	ASC	44..472	CDD:295594	113/500 (23%)
asic4a	NP_999952.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..494
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586654
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26596
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740