Protein Alignment ppk16 and ASIC2

DIOPT Version :10

• Sequence 1: NP_001334673.1
• Gene: ppk16 / 3885612
• FlyBaseID: FBgn0065108
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 129/544 - (23%)
• Similarity: 197/544 - (36%)
• Gaps: 166/544 - (30%)

  Fly    65 LHGFSYI----TRQDISRHERWFWLVVVILAIITSIVLVVVSW------YWSQETPTVTVIESSH 119
            |||..::    |....|...|..|    :||..||..| ::||      ||..
Human    66 LHGLRHMCAGRTAAGGSFQRRALW----VLAFCTSFGL-LLSWSSNRLLYWLS------------ 113

  Fly   120 FPT-------WN--IPFPAVTICN-----FNKISKSKA------LSLLDQMQVPVGINRSELHNL 164
            ||:       |:  :||||||:||     |.::||...      |.||                |
Human   114 FPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLL----------------L 162

  Fly   165 FNLTLLPV--DTMISNDSLQKYDRILS-------------LNNLTLNRLTQQLSPDCIEMISSCI 214
            .|.|..|:  :.:..::..:::.|.|:             ::...::||..||.    :|:.||.
Human   163 PNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLE----DMLLSCK 223

  Fly   215 WKGINTRC-ESLFQRIDTMEGQCCTFNYFGGISNNFPEKIAYQVPKRPYRVT---GCGYPTGLSV 275
            ::|  ..| ...|..:.|..|:|..||  .|...            :|...|   |.|  .||.:
Human   224 YRG--ELCGPHNFSSVFTKYGKCYMFN--SGEDG------------KPLLTTVKGGTG--NGLEI 270

  Fly   276 LLNPMISDY---YG----TFFSGFGFRLLLHDAYNFPDENSETKVVTTTRESFVRINP--ESTYA 331
            :|:....:|   :|    |.|.. |.::.:|       ..||...:   :|....:.|  ::..|
Human   271 MLDIQQDEYLPIWGETEETTFEA-GVKVQIH-------SQSEPPFI---QELGFGVAPGFQTFVA 324

  Fly   332 TNDIRRMDL--SLRNCLFGSEMTMHGLRRYSFINCMFECRVRMTVDLCGCLPPYVYNNGSYKVCG 394
            |.:.|...|  ....|. .|||.:.....||...|..:|..|..|:.|.|  ..|:..|....|.
Human   325 TQEQRLTYLPPPWGECR-SSEMGLDFFPVYSITACRIDCETRYIVENCNC--RMVHMPGDAPFCT 386

  Fly   395 VLQ-TNCIIHSKRLFSHALANLNFSLSIVRETDSFPCGCLPDCQSNHYVSE----STTGRLDISY 454
            ..| ..|              ...:|.::.|.||..|.|...|....|..|    ....:....|
Human   387 PEQHKEC--------------AEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKY 437

  Fly   455 FANRPTFNNA----TDRIL-LHVFFSDLMSTRYRTDIFQ----NWLSALASFGGLLGLIMGFSIV 510
            ...:  ||.:    ::.|| |.:||..|   .|.| |.|    ...:.|...||.:||.:|.||:
Human   438 LEKK--FNKSEKYISENILVLDIFFEAL---NYET-IEQKKAYEVAALLGDIGGQMGLFIGASIL 496

  Fly   511 T---AFEFIYFLTFRPVFNYINRE 531
            |   .|::||.|....:.:.:.:|
Human   497 TILELFDYIYELIKEKLLDLLGKE 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk16	NP_001334673.1	ASC	59..518	CDD:459966	126/529 (24%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	129/544 (24%)