Protein Alignment ppk16 and Scnn1b

DIOPT Version :10

• Sequence 1: NP_001334673.1
• Gene: ppk16 / 3885612
• FlyBaseID: FBgn0065108
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_036780.1
• Gene: Scnn1b / 24767
• RGDID: 3640
• Length: 638
• Species: Rattus norvegicus
• Alignment Length: 593
• Identity: 125/593 - (21%)
• Similarity: 202/593 - (34%)
• Gaps: 190/593 - (32%)

  Fly    41 PQHRFRQIGEWFTENMRNYCQTTSLHGFSYITRQDISRHERWFWLVVVILAIITSIVLVVVSWYW 105
            |.:.::::..|       ||..|:.||...|..:...:...||        ::|.:...:|.|.|
  Rat    18 PGYTYKELLVW-------YCNNTNTHGPKRIICEGPKKKAMWF--------LLTLLFACLVCWQW 67

  Fly   106 SQETPT-----VTVIESSHFPTWNIPFPAVTICNFNKISKSKALSLLDQMQVPVGINRSELHNLF 165
            .....|     |:|..|..|.|.|  |||||:||.:....||...||           .:|:.|.
  Rat    68 GVFIQTYLSWEVSVSLSMGFKTMN--FPAVTVCNSSPFQYSKVKHLL-----------KDLYKLM 119

  Fly   166 NLTLLPVDTMISNDSLQKYDRILSLNNLTL-NR----LTQQLSPDCIEMI--------------- 210
            ...|   |.:::..|  .:....|..|.|: |.    |..:.:||...::
  Rat   120 EAVL---DKILAPKS--SHTNTTSTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPG 179

  Fly   211 SSCIWKGINTRCESLFQRIDTMEGQCCTFNYFGGISNNFPEKIAYQVPK-----RPYRVTGCGY- 269
            |:|..:|    |: :..|:.:..|..|||..|...:....|....|...     .|..:.|.||
  Rat   180 STCNAQG----CK-VAMRLCSANGTVCTFRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGYA 239

  Fly   270 -------------------------------------------PT-------GLSVLLNPMISDY 284
                                                       |:       ||.::|:....||
  Rat   240 PDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDY 304

  Fly   285 YGTFFSGFGFRLLLHDAYNFPDENSETKVVTTTRESFVRI------NPESTYATNDIRRMDLSLR 343
            .....|..|.||:||:...:|....|........|:.:.:      .....|:...:...|::::
  Rat   305 VPFLASTAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLLDKLQGKGEPYSPCTMNGSDVAIQ 369

  Fly   344 NCLFGSEMTMHGLRRYSFINCMFECRVRMTVDLCGCLPPYVYN-NGSYKVCGVLQTNCIIHSKRL 407
            | |:....|     .||...|:..|.....:..|.| ..|:|. ....|.|         :::..
  Rat   370 N-LYSDYNT-----TYSIQACLHSCFQDHMIHNCSC-GHYLYPLPAGEKYC---------NNRDF 418

  Fly   408 FSHALANLNFSLSIV-RETDSFPCGCLPDCQSNHYVSESTTGRLDISYFANRPTFNNATDRILLH 471
            ...|...|:..:|:| |||      ||..|:.:   ...|..::.|| .|:.|  :.|::..:||
  Rat   419 PDWAYCYLSLQMSVVQRET------CLSMCKES---CNDTQYKMTIS-MADWP--SEASEDWILH 471

  Fly   472 V-----------------------FFSDLMSTRYRTDIFQN------WLSALASFGGLLGLIMGF 507
            |                       :|.:.   .||| |.::      ||  |::.||..|..||.
  Rat   472 VLSQERDQSSNITLSRKGIVKLNIYFQEF---NYRT-IEESPANNIVWL--LSNLGGQFGFWMGG 530

  Fly   508 SIVTAFEF 515
            |::...||
  Rat   531 SVLCLIEF 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk16	NP_001334673.1	ASC	59..518	CDD:459966	123/575 (21%)
Scnn1b	NP_036780.1	ENaC	21..621	CDD:273304	124/590 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	598..620
		PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:12654927, ECO:0000269|PubMed:8665844	614..618