DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk16 and mec-4

DIOPT Version :9

Sequence 1:	NP_001334673.1	Gene:	ppk16 / 3885612	FlyBaseID:	FBgn0065108	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_510712.2	Gene:	mec-4 / 181728	WormBaseID:	WBGene00003168	Length:	768	Species:	Caenorhabditis elegans

Alignment Length:	351	Identity:	79/351 - (22%)
Similarity:	129/351 - (36%)	Gaps:	85/351 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 QQLSPDCIEMISSCIWKGINTRCESLF-QRIDTMEGQCCTFNYFGGISNNFPEKIAYQVPKRPYR 263
            ::||....|::..|.:.|.....|:.| ..||...|.|.|||:                 .|...
Worm   437 ERLSTTKRELVHKCSFNGKACDIEADFLTHIDPAFGSCFTFNH-----------------NRTVN 484

  Fly   264 VTG--CGYPTGLSVLLNPMISDYYGTFFSGFGFRLLLHDA--YNFPDE---NSETKVVTTTRESF 321
            :|.  .|...||.:|:....|||..| ....|.||.:||.  :.|||.   ::.|..|:    ||
Worm   485 LTSIRAGPMYGLRMLVYVNASDYMPT-TEATGVRLTIHDKEDFPFPDTFGYSAPTGYVS----SF 544

  Fly   322 -VRINPESTYATNDIRRMDLSLRNCLFGSEMT--MHGLRRYSFINCMFECRVRMTVDLCGCLPPY 383
             :|:...|        |:.....:|:...:.:  ::....||...|...|..::.:..|.|..|.
Worm   545 GLRLRKMS--------RLPAPYGDCVPDGKTSDYIYSNYEYSVEGCYRSCFQQLVLKECRCGDPR 601

  Fly   384 VYNNGSYKVCGV---LQTNCIIHSKRLFSHALANLNFSLSIVRETDSFPCGCLPDCQSNHYVSES 445
            .....:.:.|..   :...|:  ..|:  :.|..|:         .||.|.|...|:.:.|
Worm   602 FPVPENARHCDAADPIARKCL--DARM--NDLGGLH---------GSFRCRCQQPCRQSIY---- 649

  Fly   446 TTGRLDISYF-ANRPTFN--------NAT----------DRILLHVFFSDLMSTRYRTDIFQNWL 491
                 .::|. |..|:.:        |.|          :..::.||:..|............::
Worm   650 -----SVTYSPAKWPSLSLQIQLGSCNGTAVECNKHYKENGAMVEVFYEQLNFEMLTESEAYGFV 709

  Fly   492 SALASFGGLLGLIMGFSIVTAFEFIY 517
            :.||.|||.|||..|.|.:|..||::
Worm   710 NLLADFGGQLGLWCGISFLTCCEFVF 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk16	NP_001334673.1	None
mec-4	NP_510712.2	deg-1	86..736	CDD:273309	79/351 (23%)
		ASC	87..>172	CDD:279230
		ASC	<428..739	CDD:295594	79/351 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162361
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.640