DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr13 and ush2a

DIOPT Version :9

Sequence 1:	NP_001033956.2	Gene:	dpr13 / 3885598	FlyBaseID:	FBgn0034286	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	XP_009291422.1	Gene:	ush2a / 568982	ZFINID:	ZDB-GENE-060503-794	Length:	5243	Species:	Danio rerio

Alignment Length:	511	Identity:	91/511 - (17%)
Similarity:	147/511 - (28%)	Gaps:	218/511 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 ASASPGGGKTVA----------ATMTTPASEPSVRHINQNLIMSQSKEGEPVPVP--QPYAQ-SA 93
            |.|.|.|..|..          :::.||.:|       ...::|..|||:.|.:.  .||:. |.
Zfish  2368 APAEPNGNLTYTVLFAGPGQNFSSLDTPDTE-------MRELLSTGKEGQWVSIGGLLPYSNYSV 2425

  Fly    94 ASAGGSSITSFDSTNVI--------DGQSQP-----TPTHLQEAVLQTHSHSRIQAKDTAGPYPI 145
            .....:|:...:|:.|.        ||...|     |||.||.:......|
Zfish  2426 MVKACNSLGCVESSPVSVSLPPGAPDGLLAPRLAAATPTSLQVSWAAPARH-------------- 2476

  Fly   146 PVHRPEPVENHLEANNGIEGGMESLFGTPMYFGTENSTVVTTQIGATAHVPCTVHHI-------- 202
              :.|..:...|:        |.|...|.::...::.| .|.....|...|.|.:|.
Zfish  2477 --NAPGALRYRLQ--------MRSSASTQLHQLMDDET-TTFSHTVTDLEPFTEYHFRLLVSNSY 2530

  Fly   203 GEGVVSWIRKKDYHLLTVGLTTYSSDERFSATHLKHSEDWTLQIKFVQLRDAGVYECQVSTHPPT 267
            ||....|:            :.:::.:|..|.......|       :|.|.|     .:|..||:
Zfish  2531 GETSSPWV------------SLFTAQDRPGAVDPPVLSD-------IQSRSA-----FISWSPPS 2571

  Fly   268 ---SIFLHLSVVEARAEITGPP-------IRYLTP--------------GSTLRLQCRVV----- 303
               .|..|.::.:.|...|..|       :.:|||              |.||..:...:
Zfish  2572 QPNGIITHYNIYQNRQLTTSVPENSTSHMLSHLTPFQQYTIQVEACTAAGCTLSAESHTINTPPA 2636

  Fly   304 -----------QNTEASEYIFWYHDNRMIN-----YDIDRGIN----VSTEPDFQSSE-LT---- 343
                       .:|..|..:.|... |::|     |.::|.::    :||....|.:: ||
Zfish  2637 PPEDVPAPQLYSDTPTSVLLSWAAP-RLVNGELDGYTVERRVSGTQEISTVATIQPNQTLTYLDS 2700

  Fly   344 --------------IQRTRREHSGNFTCVASNTQPA----------------------------- 365
                          :..||...|.:.......|:|:
Zfish  2701 SATLSPWSSYEYRIVAHTRLGGSNSSVWEKVTTRPSRPAGMQPPDGVVLGPESVQVTWAAPLIPN 2765

  Fly   366 --------------------SVLVHIFKGDNPAAMYH----------GHVGGSTKT 391
                                |:|.|...|..|...|.          |||||.|::
Zfish  2766 GEIERYEIRMPEPRIPHTNMSLLTHTVSGLMPYTGYSITILACSGGGGHVGGCTES 2821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr13	NP_001033956.2	V-set	180..276	CDD:284989	20/106 (19%)
		IG_like	182..262	CDD:214653	15/87 (17%)
		IG_like	285..362	CDD:214653	22/141 (16%)
		IGc2	292..361	CDD:197706	19/126 (15%)
ush2a	XP_009291422.1	Laminin_G_3	160..297	CDD:290121
		Laminin_N	307..528	CDD:295486
		EGF_Lam	529..577	CDD:238012
		EGF_Lam	586..638	CDD:238012
		Laminin_EGF	653..703	CDD:278482
		Laminin_EGF	706..756	CDD:278482
		EGF_Lam	759..797	CDD:214543
		Laminin_EGF	808..857	CDD:278482
		EGF_Lam	859..912	CDD:238012
		EGF_Lam	913..963	CDD:238012
		EGF_Lam	965..1014	CDD:238012
		EGF_Lam	1015..1064	CDD:238012
		FN3	1177..1253	CDD:238020
		FN3	1264..1375	CDD:238020
		FN3	1386..1469	CDD:214495
		LamG	1537..1699	CDD:238058
		LamG	1737..1890	CDD:238058
		FN3	1981..2071	CDD:238020
		FN3	2163..2253	CDD:238020
		FN3	2258..2341	CDD:238020
		FN3	2352..2443	CDD:238020	19/81 (23%)
		FN3	2447..2544	CDD:238020	23/133 (17%)
		FN3	2547..2633	CDD:238020	19/97 (20%)
		FN3	2635..2733	CDD:238020	15/98 (15%)
		FN3	2743..2807	CDD:238020	6/63 (10%)
		FN3	2830..2932	CDD:238020
		fn3	2939..3014	CDD:278470
		FN3	3032..>3099	CDD:238020
		FN3	3542..3611	CDD:238020
		FN3	3615..3701	CDD:238020
		fn3	3718..3784	CDD:278470
		FN3	3801..3887	CDD:238020
		FN3	3908..3971	CDD:238020
		FN3	3996..4086	CDD:238020
		FN3	4186..4284	CDD:238020
		fn3	4288..4366	CDD:278470
		FN3	4382..4465	CDD:238020
		FN3	4470..4553	CDD:238020
		FN3	4555..4653	CDD:238020
		FN3	4679..4753	CDD:238020
		fn3	4760..4830	CDD:278470
		FN3	4864..4955	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900