DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr13 and NCAM2

DIOPT Version :9

Sequence 1:	NP_001033956.2	Gene:	dpr13 / 3885598	FlyBaseID:	FBgn0034286	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	354	Identity:	81/354 - (22%)
Similarity:	119/354 - (33%)	Gaps:	125/354 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 QSQPTPTHLQEAVLQ-THSHSRIQAKDTAG------------PYPIPVHRP-------------- 150
            :.|| .|:.:.|:|| |.|.|:::.  :.|            |..|..:.|
Human    34 EGQP-ETYYRTALLQVTISLSKVEL--SVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQ 95

  Fly   151 -EPVENHLEA-NNGIE-GGMESLFGTPMYFGTENSTVVTT----------------QIGATAHVP 196
             |.|.:.|.. |..|| .|:.....|.....|:.:|||..                :.|..|.|.
Human    96 KEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVV 160

  Fly   197 CTVHHIGEGVVSWIRKKDYHLLTVGLTTYSSDERFSATHLKHSEDWTLQIKFVQLRDAGVYECQV 261
            |.|.......|||:    ||...|   |..||.||:.  |.::   .|||..:...|.|:|.|:
Human   161 CRVSSSPAPAVSWL----YHNEEV---TTISDNRFAM--LANN---NLQILNINKSDEGIYRCE- 212

  Fly   262 STHPPTSIFLHLSVVEARAEI---------TGPPIRYLTP---------GSTLRLQCRVVQNTEA 308
                        ..||||.||         ..||...:..         |..:...||...:.|.
Human   213 ------------GRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEP 265

  Fly   309 SEYIFWYHDNRMINYD---IDRGINVSTEPDFQSSELTIQRTRREHSGNFTCVASN--------- 361
            :  |.|:.:.::|..:   |.:|.|         :|||::.......|.:.|.|:|
Human   266 A--ISWFRNGKLIEENEKYILKGSN---------TELTVRNIINSDGGPYVCRATNKAGEDEKQA 319

  Fly   362 -----TQPASVLVHIFKGDNPAAMYHGHV 385
                 .||     ||.:..|.....:|.|
Human   320 FLQVFVQP-----HIIQLKNETTYENGQV 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr13	NP_001033956.2	V-set	180..276	CDD:284989	27/111 (24%)
		IG_like	182..262	CDD:214653	27/95 (28%)
		IG_like	285..362	CDD:214653	19/102 (19%)
		IGc2	292..361	CDD:197706	16/80 (20%)
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274	21/92 (23%)
		I-set	47..136	CDD:254352	20/90 (22%)
		I-set	142..218	CDD:254352	26/100 (26%)
		IGc2	153..214	CDD:197706	24/85 (28%)
		Ig	233..326	CDD:299845	19/103 (18%)
		I-set	240..323	CDD:254352	17/93 (18%)
		Ig5_NCAM-2	325..422	CDD:143278	7/24 (29%)
		IG_like	333..420	CDD:214653	3/11 (27%)
		IG_like	438..515	CDD:214653
		IGc2	439..507	CDD:197706
		FN3	521..613	CDD:238020
		fn3	619..703	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900