DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr13 and Kirrel3

DIOPT Version :9

Sequence 1:	NP_001033956.2	Gene:	dpr13 / 3885598	FlyBaseID:	FBgn0034286	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	XP_038937320.1	Gene:	Kirrel3 / 315546	RGDID:	1311382	Length:	869	Species:	Rattus norvegicus

Alignment Length:	405	Identity:	86/405 - (21%)
Similarity:	150/405 - (37%)	Gaps:	121/405 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PASSGLYRIKNGRVLD------------RLQKPAALIFIIAYIAACG---ICDHTASASPGGGKT 51
            ||:|.:: ::.|.|::            :.:...:.:||.......|   :|..|..|.|||.:|
  Rat   177 PAASIIW-LRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET 240

  Fly    52 VAATMTTPASEPSVRHINQNLIMSQSKEGEPVPVPQPYAQSAASAGGSSITSFDSTNVIDGQSQP 116
               ::|.....|.:  :|.::        ||.||.:           .:|.:|..:    .::.|
  Rat   241 ---SVTIDIQHPPL--VNLSV--------EPQPVLE-----------DNIVTFHCS----AKANP 277

  Fly   117 TPTHLQEAVLQTHSHSRIQAKDTAGP-YPIPV---HRPEPVENHLEANNGIEGGMESLFGT-PMY 176
            ..|..:.|   ...|.   .|:.:|. |...|   :..|||.  .|..|.:  |..:|..| .:|
  Rat   278 AVTQYRWA---KRGHI---IKEASGELYRTTVDYTYFSEPVS--CEVTNAL--GSTNLSRTVDVY 332

  Fly   177 FG---TENSTVVTTQIGATAHVPCTVHHIGEGVVSWIRKKDYHLLTVGLTTYSSDERFSATHLKH 238
            ||   |.....:...:|:.|...|          :||......::.:        :|.|...|
  Rat   333 FGPRMTSEPQSLLVDLGSDAVFSC----------AWIGNPSLTIVWM--------KRGSGVVL-- 377

  Fly   239 SEDWTLQIKFVQLRDAGVYECQVSTHPPTSIFLHLSVV--------EARAEITGPPI------RY 289
            |.:.||.:|.|:..|||.|.|:             :||        |....:.||||      ::
  Rat   378 SNEKTLTLKSVRQEDAGKYVCR-------------AVVPRVGAGEREVTLTVNGPPIISSTQTQH 429

  Fly   290 LTPGSTLRLQCRVVQNTEASEYIFWYHDNRMI------NYDIDRGINVSTEPDFQSSELTIQR-T 347
            ...|...:::| .:::|...:.|.|.....::      .|.::   .|:||....|: |||.. .
  Rat   430 ALHGEKGQIKC-FIRSTPPPDRIAWSWKENVLESGTSGRYTVE---TVNTEEGVIST-LTISNIV 489

  Fly   348 RREHSGNFTCVASNT 362
            |.:....:.|.|.|:
  Rat   490 RADFQTIYNCTAWNS 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr13	NP_001033956.2	V-set	180..276	CDD:284989	18/95 (19%)
		IG_like	182..262	CDD:214653	18/79 (23%)
		IG_like	285..362	CDD:214653	19/89 (21%)
		IGc2	292..361	CDD:197706	16/75 (21%)
Kirrel3	XP_038937320.1	IG_like	54..143	CDD:214653
		Ig strand A'	56..60	CDD:409353
		Ig strand B	64..71	CDD:409353
		Ig strand C	78..82	CDD:409353
		Ig strand C'	84..87	CDD:409353
		Ig strand D	97..101	CDD:409353
		Ig strand E	104..116	CDD:409353
		Ig strand G	132..143	CDD:409353
		IgI_2_KIRREL3-like	149..246	CDD:409416	16/72 (22%)
		Ig strand B	166..170	CDD:409416
		Ig strand C	180..184	CDD:409416	1/4 (25%)
		Ig strand E	210..214	CDD:409416	0/3 (0%)
		Ig strand F	224..229	CDD:409416	1/4 (25%)
		Ig strand G	239..242	CDD:409416	1/5 (20%)
		Ig	<267..334	CDD:416386	18/80 (23%)
		Ig strand B	267..274	CDD:409353	1/10 (10%)
		Ig strand C	279..286	CDD:409353	2/9 (22%)
		Ig strand C'	288..291	CDD:409353	1/5 (20%)
		Ig strand D	298..302	CDD:409353	1/3 (33%)
		Ig strand E	304..310	CDD:409353	0/5 (0%)
		Ig strand G	321..334	CDD:409353	4/12 (33%)
		Ig	335..416	CDD:416386	22/113 (19%)
		Ig strand A'	343..347	CDD:409353	0/3 (0%)
		Ig strand B	350..360	CDD:409353	3/19 (16%)
		Ig strand C	365..371	CDD:409353	0/13 (0%)
		Ig strand E	381..387	CDD:409353	2/5 (40%)
		IgI_5_KIRREL3	418..515	CDD:409479	21/92 (23%)
		Ig strand B	436..440	CDD:409479	0/3 (0%)
		Ig strand C	450..454	CDD:409479	1/3 (33%)
		Ig strand E	481..485	CDD:409479	2/4 (50%)
		Ig strand F	496..501	CDD:409479	1/4 (25%)
		Ig strand G	509..512	CDD:409479
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810