DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr13 and DSCAM

DIOPT Version :9

Sequence 1:NP_001033956.2 Gene:dpr13 / 3885598 FlyBaseID:FBgn0034286 Length:419 Species:Drosophila melanogaster
Sequence 2:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens


Alignment Length:435 Identity:96/435 - (22%)
Similarity:150/435 - (34%) Gaps:113/435 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 PASSGLY------RIKNGRVLDRLQKPAALIFIIAYIAACGICDHTASASPGGGKTVAATMT--- 57
            |:.||.|      |....:|:.||.....|        ...|......:|.|...:::.::|   
Human   285 PSDSGSYVCEVSNRYGTAKVIGRLYVKQPL--------KATISPRKVKSSVGSQVSLSCSVTGTE 341

  Fly    58 -------------TPASEPSVRHIN-QNLIMSQSKEGEPVPV----------PQPYAQSAASAGG 98
                         .|.....:..|| :||||....:.:....          .|.|.|.....|.
Human   342 DQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGT 406

  Fly    99 SSITSFDSTNVID------------GQSQPTPTHL--QEAVLQTHSHSRIQAKDTAGPYPIPVHR 149
            ..|.|..|..|:.            |...||.|..  .:.:|:..||...|...:.|        
Human   407 PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEG-------- 463

  Fly   150 PEPVENHLEANNG--IEGGMESLFGTPMYFGTENST--VVTTQIGATAHVPCTVHHIGEGVVSWI 210
              .|.::|..::.  .:||        :|..|.|::  ||..|.......|.::..:..  ::.|
Human   464 --NVVSYLNISSSQVRDGG--------VYRCTANNSAGVVLYQARINVRGPASIRPMKN--ITAI 516

  Fly   211 RKKD--YHLLTVGLTTY-------SSDERFSATHLKHSEDWTLQIKFVQLR-DAGVYECQVSTHP 265
            ..:|  .|...:|...|       |:...|:...:....:.||::..||.. |.|.|.|.|...|
Human   517 AGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQP 581

  Fly   266 --PTSIFLHLSVVEARAEITGPPIRYLTP--------GSTLRLQCRVVQNTEASEYIFWYHDNRM 320
              .||..:|::|       ..||  ::.|        |..:.:.| ||.:.:....|.|..|.|.
Human   582 QLSTSQSVHVTV-------KVPP--FIQPFEFPRFSIGQRVFIPC-VVVSGDLPITITWQKDGRP 636

  Fly   321 INYDIDRGINVSTEPDFQSSELTIQRTRREHSGNFTCVASNTQPA 365
            |...:  |:.:. ..||.|| |.|......|:||:||:|.|...|
Human   637 IPGSL--GVTID-NIDFTSS-LRISNLSLMHNGNYTCIARNEAAA 677

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr13NP_001033956.2 V-set 180..276 CDD:284989 25/109 (23%)
IG_like 182..262 CDD:214653 19/91 (21%)
IG_like 285..362 CDD:214653 25/84 (30%)
IGc2 292..361 CDD:197706 23/76 (30%)
DSCAMNP_001380.2 Ig 45..113 CDD:319273
I-set 235..310 CDD:254352 8/24 (33%)
I-set 315..385 CDD:333254 11/69 (16%)
Ig_3 407..488 CDD:316449 19/98 (19%)
IGc2 518..575 CDD:197706 13/56 (23%)
I-set 596..686 CDD:333254 27/89 (30%)
Ig_DSCAM 707..784 CDD:143211
Ig 802..889 CDD:325142
FN3 885..978 CDD:238020
FN3 986..1083 CDD:238020
FN3 1091..1184 CDD:238020
FN3 1189..1278 CDD:238020
Ig 1303..1369 CDD:319273
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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