DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr13 and Dscaml1

DIOPT Version :9

Sequence 1:	NP_001033956.2	Gene:	dpr13 / 3885598	FlyBaseID:	FBgn0034286	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_001074739.2	Gene:	Dscaml1 / 114873	MGIID:	2150309	Length:	2053	Species:	Mus musculus

Alignment Length:	361	Identity:	82/361 - (22%)
Similarity:	122/361 - (33%)	Gaps:	96/361 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 MTTPASEPSVRHI-NQNLIMSQSKEG----------EPVPVPQPYAQSAASAGGSSITSFDSTNV 109
            :..|....|:|.: |:.|::|.:::.          ......|.:|......|...|.|..|..|
Mouse   354 LVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIVSSFSEKV 418

  Fly   110 ID------------GQSQPTPTHL--QEAVLQTHSH----------SRIQAKDTAGPY--PIPVH 148
            ::            |...||.|..  .|.|::..||          :.|...:..||.  ...|:
Mouse   419 VNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVY 483

  Fly   149 RPEPVENHLEANNGIEGGME-----SLFGTPMYFGTENSTVVTTQIGATAHVPCTVHHIGEGVVS 208
            |       ..|.|.: |..|     ::.|.|......|.|.|.   |....:.|.|.......:.
Mouse   484 R-------CTARNSV-GSAEYQARINVRGPPSIRAMRNITAVA---GRDTLINCRVIGYPYYSIK 537

  Fly   209 WIRK----KDYHLLTVGLTTYSSDERFSATHLKHSEDWTLQIKFVQL-RDAGVYECQVSTHPPTS 268
            |.:.    .|.|...|                  .|:.||::..||. .|.|.|.|.|...|..|
Mouse   538 WYKDALLLPDNHRQVV------------------FENGTLKLTDVQKGMDEGEYLCSVLIQPQLS 584

  Fly   269 IFLHLSVVEARAEITGPPIRYLTP--------GSTLRLQCRVVQNTEASEYIFWYHDNRMINYDI 325
            |...:.|.     :..||:  :.|        |..|.:.| ||.:.:....|.|..|.::    |
Mouse   585 ISQSVHVA-----VKVPPL--IQPFEFPPASIGQLLYIPC-VVSSGDMPIRITWRKDGQV----I 637

  Fly   326 DRGINVSTEPDFQSSELTIQRTRREHSGNFTCVASN 361
            ..|..|:.|.....|.|.|.....:|:||:||:|||
Mouse   638 ISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASN 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr13	NP_001033956.2	V-set	180..276	CDD:284989	23/100 (23%)
		IG_like	182..262	CDD:214653	18/84 (21%)
		IG_like	285..362	CDD:214653	26/85 (31%)
		IGc2	292..361	CDD:197706	22/76 (29%)
Dscaml1	NP_001074739.2	IGc2	43..110	CDD:197706
		Ig	125..218	CDD:353325
		I-set	226..311	CDD:336764
		Ig_3	317..389	CDD:339005	6/34 (18%)
		Ig	408..498	CDD:353325	21/97 (22%)
		IGc2	519..577	CDD:197706	16/75 (21%)
		Ig	615..681	CDD:319273	21/64 (33%)
		Ig_DSCAM	707..785	CDD:143211
		Ig	803..891	CDD:353325
		FN3	887..981	CDD:238020
		FN3	988..1085	CDD:238020
		FN3	1093..1186	CDD:238020
		FN3	1191..1282	CDD:238020
		Ig	1307..1377	CDD:319273
		FN3	1384..1474	CDD:238020
		FN3	1488..1560	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1716..1741
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1773..1803
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1840..1862
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1974..2053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810