DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and KLK4

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_004908.4	Gene:	KLK4 / 9622	HGNCID:	6365	Length:	254	Species:	Homo sapiens

Alignment Length:	275	Identity:	67/275 - (24%)
Similarity:	110/275 - (40%)	Gaps:	52/275 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IGLVLCQGLAQLLDKKCHDPKTSENINFNHGATETAPWMASIYKNNQFICDGTLVHKLFVLTAAS 74
            :|.::......|:...|     |:.||....:..:.||.|::...|:..|.|.|||..:||:||.
Human    12 LGYLILGVAGSLVSGSC-----SQIINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAH 71

  Fly    75 CISKDSQLYVL-FGMYNQYRDASQFFNNEQYGVAVALQHSNFRPNNGVNDIGLLRLYGEVTHYAH 138
            |....   |.: .|:::  .:|.|...::....:::::|..:......||:.|::|...|:....
Human    72 CFQNS---YTIGLGLHS--LEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESDT 131

  Fly   139 IRPI------------CIILDHVVKSAPFERFEGFGWQQQGTEASSQVRQTVYLSQKKPFECHRN 191
            ||.|            |::               .||..........|.|.|.:|......|.:.
Human   132 IRSISIASQCPTAGNSCLV---------------SGWGLLANGRMPTVLQCVNVSVVSEEVCSKL 181

  Fly   192 GQLLPINEGQFCA--GNRDRSFCRSNSGSPLTADFTYGVKNITVQVGLVSYGSELCSPT---SVY 251
            ...| .:...|||  |...:..|..:||.||       :.|..:| ||||:|...|...   .||
Human   182 YDPL-YHPSMFCAGGGQDQKDSCNGDSGGPL-------ICNGYLQ-GLVSFGKAPCGQVGVPGVY 237

  Fly   252 TDVVAFKDWIYNTVR 266
            |::..|.:||..||:
Human   238 TNLCKFTEWIEKTVQ 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	59/235 (25%)
		Tryp_SPc	46..261	CDD:214473	57/232 (25%)
		Tryp_SPc	293..484	CDD:304450
		Tryp_SPc	293..481	CDD:214473
KLK4	NP_004908.4	Tryp_SPc	31..250	CDD:238113	61/247 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910