DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	365	Identity:	87/365 - (23%)
Similarity:	144/365 - (39%)	Gaps:	89/365 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KTSENINFNHGATETAPWMASIYKNNQFICDGTLVHKLFVLTAASCISKDSQLY---VLFGMYNQ 91
            ||...:.....:.::.||..||..:.|.:|.|:::...:|||||.|..|.:.::   |..|
Human   201 KTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAG---- 261

  Fly    92 YRDASQFFNNEQYGVAVALQHSNFRPNNGVNDIGLLRLYGEVTHYAHIRPICI-ILDHVVKSAPF 155
             .|....|.:......:.::.:...|.:  |||.|::|...:|....:||||: ..|..:..|..
Human   262 -SDKLGSFPSLAVAKIIIIEFNPMYPKD--NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATP 323

  Fly   156 ERFEGFGWQQQG--------TEASSQVRQTVYLSQKKPFECHRNGQLLPINEGQFCAGNRDRSF- 211
            ....|:|:.:|.        .:||.||..:...:....::    |:   :.|...|||..:...
Human   324 LWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQ----GE---VTEKMMCAGIPEGGVD 381

  Fly   212 -CRSNSGSPLTADFTYGVKNITVQVGLVSYGSELCSPTS--VYTDVVAFKDWIYNTVRNFETKGD 273
             |:.:||.||    .|......| ||:||:|.....|::  |||.|.|:.:||||..:      |
Human   382 TCQGDSGGPL----MYQSDQWHV-VGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWK------D 435

  Fly   274 QVVYEECRSNWAEDVLVRLWEVSLHQNTFSGVLITNRFVLTVASAFPNIPLVMKVETKYLKSFDV 338
            :.:...|.|                  ..:|::|..          |.:||:      .|:|
Human   436 RTIQRSCNS------------------PGTGLVIQQ----------PAVPLM------ELRS--- 463

  Fly   339 ESIHTHPRFTHSSMDNNIALLKLAHDVPNSDLVKPICIVP 378
             :.||| |.|     ..:..|..    |....:.|:|..|
Human   464 -ARHTH-RLT-----TCVCFLSF----PALQPLSPLCPFP 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	64/233 (27%)
		Tryp_SPc	46..261	CDD:214473	61/230 (27%)
		Tryp_SPc	293..484	CDD:304450	17/86 (20%)
		Tryp_SPc	293..481	CDD:214473	17/86 (20%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335
		Tryp_SPc	204..429	CDD:214473	61/243 (25%)
		Tryp_SPc	205..432	CDD:238113	64/245 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910