DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and PROC

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_024308770.1	Gene:	PROC / 5624	HGNCID:	9451	Length:	576	Species:	Homo sapiens

Alignment Length:	279	Identity:	72/279 - (25%)
Similarity:	112/279 - (40%)	Gaps:	48/279 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DPKTSENINFNHGATETAPWMASIY-KNNQFICDGTLVHKLFVLTAASCISKDSQLYVLFGMYNQ 91
            ||:..:......|   .:||...:. ...:..|...|:|..:|||||.|:.:..:|.|..|.|:.
Human   324 DPRLIDGKMTRRG---DSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDL 385

  Fly    92 YR--------DASQFFNNEQYGVAVALQHSNFRPNNGVNDIGLLRLYGEVTHYAHIRPICI---- 144
            .|        |..:.|           .|.|:..:...|||.||.|....|....|.|||:
Human   386 RRWEKWELDLDIKEVF-----------VHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSG 439

  Fly   145 ILDHVVKSAPFERF-EGFGWQQQGTEASSQVRQTVYLSQKKPFECHRN-GQLLP--INEGQFCAG 205
            :.:..:..|..|.. .|:|:.....:.:.:.|..|....|.|...|.. .:::.  ::|...|||
Human   440 LAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAG 504

  Fly   206 --NRDRSFCRSNSGSPLTADFTYGVKNITVQVGLVSYGS--ELCSPTSVYTDVVAFKDWIYNTVR 266
              ...:..|..:||.|:.|.| :|...:   |||||:|.  .|.....|||.|..:.|||:..:|
Human   505 ILGDRQDACEGDSGGPMVASF-HGTWFL---VGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIR 565

  Fly   267 NFETKGDQVVYEECRSNWA 285
            :.|..         :.:||
Human   566 DKEAP---------QKSWA 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	65/238 (27%)
		Tryp_SPc	46..261	CDD:214473	63/235 (27%)
		Tryp_SPc	293..484	CDD:304450
		Tryp_SPc	293..481	CDD:214473
PROC	XP_024308770.1	GLA	117..168	CDD:214503
		EGF_CA	182..213	CDD:238011
		FXa_inhibition	255..290	CDD:317114
		Tryp_SPc	328..563	CDD:238113	66/252 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910