DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and PLAU

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens

Alignment Length:	297	Identity:	71/297 - (23%)
Similarity:	116/297 - (39%)	Gaps:	72/297 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QLLDKKC--HD------PKT-SENINFNHG----------------ATETAPWMASIYKNNQ--- 56
            :||.::|  ||      |.: .|.:.|..|                ..|..||.|:||:.::
Human   140 KLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGS 204

  Fly    57 --FICDGTLVHKLFVLTAASCI----SKDSQLYVLFGMYNQYRDASQFFNNEQ----YGVAVALQ 111
              ::|.|:|:...:|::|..|.    .|:.        |..|...|:..:|.|    :.|...:.
Human   205 VTYVCGGSLISPCWVISATHCFIDYPKKED--------YIVYLGRSRLNSNTQGEMKFEVENLIL 261

  Fly   112 HSNFRPNNGV--NDIGLLRLYGEVTHYAH----IRPICIILDHVVKSAPFE---RFEGFGWQQQG 167
            |.::..:...  |||.||::..:....|.    |:.||  |..:.....|.   ...||| ::..
Human   262 HKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTIC--LPSMYNDPQFGTSCEITGFG-KENS 323

  Fly   168 TE--ASSQVRQTV--YLSQKKPFECHRNGQLLPINEGQFCAGNRD--RSFCRSNSGSPLTADFTY 226
            |:  ...|::.||  .:|.::..:.|..|.  .:.....||.:..  ...|:.:||.||.... .
Human   324 TDYLYPEQLKMTVVKLISHRECQQPHYYGS--EVTTKMLCAADPQWKTDSCQGDSGGPLVCSL-Q 385

  Fly   227 GVKNITVQVGLVSY--GSELCSPTSVYTDVVAFKDWI 261
            |...:|   |:||:  |..|.....|||.|..|..||
Human   386 GRMTLT---GIVSWGRGCALKDKPGVYTRVSHFLPWI 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	61/246 (25%)
		Tryp_SPc	46..261	CDD:214473	59/244 (24%)
		Tryp_SPc	293..484	CDD:304450
		Tryp_SPc	293..481	CDD:214473
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056	5/11 (45%)
		Connecting peptide	152..177		4/24 (17%)
		Tryp_SPc	179..422	CDD:238113	62/258 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910