DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and AgaP_AGAP012502

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_001230484.2	Gene:	AgaP_AGAP012502 / 4578454	VectorBaseID:	AGAP012502	Length:	829	Species:	Anopheles gambiae

Alignment Length:	494	Identity:	115/494 - (23%)
Similarity:	200/494 - (40%)	Gaps:	91/494 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 CDGTLVHKLFVLTAASCI-SKDSQL---YVLFGMYNQYRDASQFFNNEQYGVAVALQHSNFRPNN 119
            |.|:|:...|:||||.|. .:|:.|   .:..|..|.|.|.......|:..:.| ::|..:..::
Mosquito    46 CGGSLIWANFILTAAHCTKDRDTLLPPDIIRIGDLNLYDDREDALVQERTIIRV-IRHPLYNTSS 109

  Fly   120 GVNDIGLLRLYGEVTHYAHIRPICIILDHVVKSAPFERFEGFGWQQQG---TEASSQVRQTVYLS 181
            ...||.||.|..:|..|..:.|.|:.||   .:.||.:.|..||...|   .:.:..::..:.|.
Mosquito   110 VFYDIALLMLNEKVNIYFEVMPTCLWLD---DNIPFSKVEAAGWGTSGFGYGKTNILIKAELKLM 171

  Fly   182 QKKPFECH-------RNGQLLPINEGQFCAGNRDRSFCRSNSGSPLTADFTYGVKNITVQVGLVS 239
            ..|..|.:       :||    :.|.|.||.::....|..:||.||.....:|...:...||:.|
Mosquito   172 ANKDCESYYSQVASVKNG----LMEHQLCAWDKVMDTCPGDSGGPLQHKLIFGDYKVPFLVGVTS 232

  Fly   240 YGSELC--SPTSVYTDVVAFKDWIYNTVRNFETKGDQVVYE--EC-------RSNWAEDVL---- 289
            :|.. |  |...||..|..|..||..|::....:....::|  .|       |..:...:.
Mosquito   233 FGLS-CGNSQPGVYVKVSKFGSWIVETLQQHGERVTAAMFEPLACAGRYFYHRERYGPSIFDIRP 296

  Fly   290 --VRL-------------WEVSLHQNTFS--GVLITNRFVLTVASAF---PNIPLVMKV-----E 329
              |:|             ||...... |.  |.||:.|.|:|.||..   .:.|.::::     .
Mosquito   297 HNVQLIWPKQPSPERCSGWETETDVK-FECYGCLISTRGVVTAASCLRLRSSNPTIVRLGEQGWT 360

  Fly   330 TKYLKSFDVESIHTHPRFTHSSMDNNIALLKLAHDVPNSDLVKPICIVPSPKLPRMLTTLVDETT 394
            ..:|....:|:...|||:..::.:::||::||...:.....:.|:|:..:.....:...::....
Mosquito   361 NSHLIFRLIEATTVHPRYNETTGEHDIAVIKLKEAIHPFVHLFPVCLWQNTTHSPVHQAIMHSAP 425

  Fly   395 NDFRGVRNVTLNAINHIECARRIGK--------PLKSNQFCVAQPIDFKVQAPGS---IIG--TY 446
            ..:...:   |||:::.....||.|        .|:...||...  |..| |||:   ::|  .|
Mosquito   426 LTYEPAK---LNAMSYDNHTCRINKQSFGASPQSLQRELFCFGN--DESV-APGACYLVLGGPIY 484

  Fly   447 RNIGDGNRYYLFGLMSYSKD-GM---VVYTYIQSYLDWI 481
            ::    :..:.:||....:| |.   .|...::||..|:
Mosquito   485 KS----SSPFPYGLNLLGRDCGFGKPAVGLLLKSYKLWL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	62/220 (28%)
		Tryp_SPc	46..261	CDD:214473	60/217 (28%)
		Tryp_SPc	293..484	CDD:304450	47/216 (22%)
		Tryp_SPc	293..481	CDD:214473	46/214 (21%)
AgaP_AGAP012502	XP_001230484.2	Tryp_SPc	19..258	CDD:238113	62/220 (28%)
		Tryp_SPc	19..255	CDD:214473	60/217 (28%)
		Tryp_SPc	325..>418	CDD:304450	20/92 (22%)
		Trypsin	621..823	CDD:278516
		Tryp_SPc	629..826	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910