DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and AgaP_AGAP000411

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_001237291.3	Gene:	AgaP_AGAP000411 / 4576124	VectorBaseID:	AGAP000411	Length:	1091	Species:	Anopheles gambiae

Alignment Length:	564	Identity:	127/564 - (22%)
Similarity:	226/564 - (40%)	Gaps:	129/564 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CHDPKTSENINFNHGATETA---PWMASIY----KNNQFICDGTLVHKLFVLTAASCISKDS--- 80
            |...|.......::||...|   ||.|:|:    |:.::.|.|:::.:..:|||:.|:|..|
Mosquito    12 CGRRKVKTTYLIHNGADAIAGHWPWHAAIFHQKDKHKEYACGGSILDETTILTASHCVSTLSGVI 76

  Fly    81 ----------QLYVLFGMYNQYRDASQFFNNEQYGVAVALQHSNFRPNNGVNDIGLLRLYGEVTH 135
                      |:::     ||..:.:|.|...:     .:.:..|...:.::||.|::|...::.
Mosquito    77 SAALVTVHVGQIHL-----NQSSEYTQTFEARE-----IIINPGFSKASIIHDIALIKLRTNISM 131

  Fly   136 YAHIRPICI-ILDHVVKSAPFER--FEGFGWQQQGTEASSQVRQTVYLSQKKPFECHRNGQLL-- 195
            ..:::|:|: .:|..::......  ..|||..::.. .|.|::|.. :....|:.|..:.:::
Mosquito   132 NRYVQPVCLWTMDSALELIVGRNGTIVGFGLSERDV-VSEQLKQAT-IGVVDPYTCIASDRVVYG 194

  Fly   196 -PINEGQFCA-GNRDRSFCRSNSGSPLTAD-----FTYGVKNITVQVGLVSYGSELCSPT--SVY 251
             .:....||. |....|.|..:||..:..:     |..|:.:.|...|    .|.||.|.  :||
Mosquito   195 THLTLEMFCGKGQNGVSACNGDSGGGMFFEVSGRWFVRGLVSFTPARG----SSGLCDPLKYTVY 255

  Fly   252 TDVVAFKDWI--YNTVRNFETKGD--QVVYEE--------------CRSN---WAEDV------- 288
            |||..:.:||  |...|....:.|  :|.|||              .||.   |...|
Mosquito   256 TDVAKYVEWIKQYIDQRVLPVESDVLEVDYEEKLRLFNFGSCGVLDARSKFIPWLGAVKLPNDNR 320

  Fly   289 ------LVRLWEVSLHQNTFSGVLITNRFVLTVASAFPNIPLVMKVETKYLKSFD---------- 337
                  |:..|......:.|:.|.:....:|      .|:|.....:..|..:.:
Mosquito   321 TRCMVTLISEWYAVGPAHCFNTVGVIPYILL------GNVPDETTSQCTYSTNIEDCMVFEQTRK 379

  Fly   338 VESIHTHPRFTHSSMDNNIALLKLAHDV----PNSDLVKPICIVPSPKLPRMLTTLVDETTNDFR 398
            ::.|..||:|..::..:|||||:|....    ||   |:|||:..:|:|.....|.:.......|
Mosquito   380 IQRIVVHPKFGPNNSADNIALLELLTPADTSQPN---VQPICMPVTPELRTNAKTNLSVVAIARR 441

  Fly   399 GVR--NVTLNAINHIECAR-----RIGKPLKSNQFCVAQPIDFKVQ-----APGSIIGTYRNIGD 451
            |:|  |:|:..:..:||.|     :|...|:..:.|..||...:.:     ..|..|...:..|.
Mosquito   442 GLRQQNITVRFVEPVECTRQYAEQKIELKLEFKRMCAVQPSKREERFCYSLTEGVPIQEMKIFGG 506

  Fly   452 GNRYYLFGLMSYSKDGMV-------VYTYIQSYLDWIMDKVYYN 488
            ..:|:|.|   :...|..       :|..|::|:|||:..:.||
Mosquito   507 KEQYFLRG---FELTGAACSTITPSIYNNIEAYVDWILYNMRYN 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	57/250 (23%)
		Tryp_SPc	46..261	CDD:214473	54/245 (22%)
		Tryp_SPc	293..484	CDD:304450	52/223 (23%)
		Tryp_SPc	293..481	CDD:214473	50/220 (23%)
AgaP_AGAP000411	XP_001237291.3	Tryp_SPc	23..267	CDD:238113	59/259 (23%)
		Tryp_SPc	25..265	CDD:214473	57/255 (22%)
		Tryp_SPc	308..>462	CDD:304450	37/162 (23%)
		Trypsin	838..1069	CDD:278516
		Tryp_SPc	864..>946	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910