DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and OVCH2

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_016873148.1	Gene:	OVCH2 / 341277	HGNCID:	29970	Length:	569	Species:	Homo sapiens

Alignment Length:	413	Identity:	111/413 - (26%)
Similarity:	164/413 - (39%)	Gaps:	97/413 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PWMASIYKNNQFICDGTLVHKLFVLTAASCISKD---SQLYVLFGMYNQYRDASQFFNNEQ-YGV 106
            ||..|:.:..:.||.|::|...:|:|||.||:..   |.|.|..|.|    |.||....|| ..:
Human    68 PWQVSLKQRQKHICGGSIVSPQWVITAAHCIANRNIVSTLNVTAGEY----DLSQTDPGEQTLTI 128

  Fly   107 AVALQHSNFRPNNGVN-DIGLLRLYGEVTHYAHIRPICIILDHVVKSAP--FERFE-GF-----G 162
            ...:.|.:|.....:: ||.||::.|.......:.|||:         |  .|:|| ||     |
Human   129 ETVIIHPHFSTKKPMDYDIALLKMAGAFQFGHFVGPICL---------PELREQFEAGFICTTAG 184

  Fly   163 WQQQGTEAS--SQVRQTVYLSQKKPFECHRNGQLL----PINEGQF-CAGNRD--RSFCRSNSGS 218
            |.:. ||..  |||.|.|.|......||  ...||    ||:...| |.|..|  |..|:.:||.
Human   185 WGRL-TEGGVLSQVLQEVNLPILTWEEC--VAALLTLKRPISGKTFLCTGFPDGGRDACQGDSGG 246

  Fly   219 PLTADFTYGVKNITVQVGLVSYG-------------SELCSPTSVYTDVVAFKDWIYNTVRNFET 270
            .|......|...:   .|:.|:|             |:..|| .::||:.....||:..::.
Human   247 SLMCRNKKGAWTL---AGVTSWGLGCGRGWRNNVRKSDQGSP-GIFTDISKVLPWIHEHIQT--- 304

  Fly   271 KGDQVVYEECRSNWA--EDVLVRLWEVSLHQNTFSGVL-----ITNRFVLTVASAFPNIPLVMKV 328
             |::   .:....|.  :||:|...|..||   |...|     ...|.|.|         |::..
Human   305 -GNR---RKSSRAWCSEQDVIVSGAEGKLH---FPESLHLYYESKQRCVWT---------LLVPE 353

  Fly   329 ETKYLKSF---DVESIHTHPRFTHSSMDNNIALLKLAHDVPNSDLVKPICIVPSPKLPRMLTTLV 390
            |...|.||   ||||.| |...:..|:::..........:|:|.|:..         ..:....|
Human   354 EMHVLLSFSHLDVESCH-HSYLSMYSLEDRPIGKFCGESLPSSILIGS---------NSLRLKFV 408

  Fly   391 DETTNDFRGVRNVTLNAI--NHI 411
            .:.|::..|. |:|..|:  |:|
Human   409 SDATDNAAGF-NLTYKALKPNYI 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	75/252 (30%)
		Tryp_SPc	46..261	CDD:214473	73/249 (29%)
		Tryp_SPc	293..484	CDD:304450	31/129 (24%)
		Tryp_SPc	293..481	CDD:214473	31/129 (24%)
OVCH2	XP_016873148.1	Tryp_SPc	55..298	CDD:214473	73/249 (29%)
		Tryp_SPc	56..301	CDD:238113	75/252 (30%)
		CUB	320..424	CDD:238001	30/126 (24%)
		CUB	435..546	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910