DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and GZMB

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_004122.2	Gene:	GZMB / 3002	HGNCID:	4709	Length:	247	Species:	Homo sapiens

Alignment Length:	249	Identity:	62/249 - (24%)
Similarity:	102/249 - (40%)	Gaps:	34/249 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ENINFNHGATETAPWMASIY---KNNQFICDGTLVHKLFVLTAASCISKDSQLYVLFGMYN--QY 92
            |.|..:.....:.|:||.:.   :.:...|.|.|:...||||||.|..  |.:.|..|.:|  :.
Human    20 EIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWG--SSINVTLGAHNIKEQ 82

  Fly    93 RDASQFFNNEQYGVAVALQHSNFRPNNGVNDIGLLRLYGEVTHYAHIRPICIILDHVVKSAPFER 157
            ....||.     .|...:.|..:.|.|..|||.||:|..:......::|: .:..:..:..|.:.
Human    83 EPTQQFI-----PVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPL-RLPSNKAQVKPGQT 141

  Fly   158 FEGFGWQQ-----QGTEASSQVRQTVYLSQKKPFECHRNGQLLPINEGQFCAGN---RDRSFCRS 214
            ....||.|     :.:....:|:.||...:|    |..:.:....:..:.|.|:   :..|| :.
Human   142 CSVAGWGQTAPLGKHSHTLQEVKMTVQEDRK----CESDLRHYYDSTIELCVGDPEIKKTSF-KG 201

  Fly   215 NSGSPLTADFTYGVKNITVQVGLVSYGSELCSPTSVYTDVVAFKDWIYNTVRNF 268
            :||.||..:        .|..|:||||.....|....|.|.:|..||..|::.:
Human   202 DSGGPLVCN--------KVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTMKRY 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	59/230 (26%)
		Tryp_SPc	46..261	CDD:214473	57/227 (25%)
		Tryp_SPc	293..484	CDD:304450
		Tryp_SPc	293..481	CDD:214473
GZMB	NP_004122.2	Tryp_SPc	20..240	CDD:214473	59/240 (25%)
GZMB	NP_004122.2	Tryp_SPc	21..243	CDD:238113	60/242 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910